Lipid metabolism in the perfused chicken liver. The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid
Comparative studies were made of the uptake and metabolism of cis- and trans-octadecenoic acids by the perfused chicken liver. No differences were observed in the rates of uptake of the isomers. There was considerable incorporation of radioactivity into triglycerides and phospholipids, and some rele...
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| Veröffentlicht in: | Biochemical journal 1970-07, Vol.118 (3), p.433-442 |
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| creator | Bickerstaffe, R Annison, E F |
| description | Comparative studies were made of the uptake and metabolism of cis- and trans-octadecenoic acids by the perfused chicken liver. No differences were observed in the rates of uptake of the isomers. There was considerable incorporation of radioactivity into triglycerides and phospholipids, and some release of labelled lipid into the perfusate was observed. The cis-fatty acids were more readily incorporated into triglycerides than phospholipids, the reverse being true of the trans-fatty acids. Examination of the intramolecular distribution of fatty acids in triglycerides showed that the trans-fatty acid and stearate mainly occupied the 1- and 3-positions, and cis-fatty acids the 2-position. In the phospholipids phosphatidylcholine and phosphatidylethanolamine the trans-fatty acids again behaved like stearic acid and favoured the 1-position. No evidence was obtained of atypical patterns of uptake or metabolism of the trans-fatty acids. |
| doi_str_mv | 10.1042/bj1180433 |
| format | Article |
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The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Bickerstaffe, R ; Annison, E F</creator><creatorcontrib>Bickerstaffe, R ; Annison, E F</creatorcontrib><description>Comparative studies were made of the uptake and metabolism of cis- and trans-octadecenoic acids by the perfused chicken liver. No differences were observed in the rates of uptake of the isomers. There was considerable incorporation of radioactivity into triglycerides and phospholipids, and some release of labelled lipid into the perfusate was observed. The cis-fatty acids were more readily incorporated into triglycerides than phospholipids, the reverse being true of the trans-fatty acids. Examination of the intramolecular distribution of fatty acids in triglycerides showed that the trans-fatty acid and stearate mainly occupied the 1- and 3-positions, and cis-fatty acids the 2-position. In the phospholipids phosphatidylcholine and phosphatidylethanolamine the trans-fatty acids again behaved like stearic acid and favoured the 1-position. No evidence was obtained of atypical patterns of uptake or metabolism of the trans-fatty acids.</description><identifier>ISSN: 0264-6021</identifier><identifier>ISSN: 0306-3283</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj1180433</identifier><identifier>PMID: 5472169</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Carbon Isotopes ; Chickens ; Chromatography, Gas ; Fatty Acids - metabolism ; In Vitro Techniques ; Liver - metabolism ; Methylation ; Oleic Acids - metabolism ; Perfusion ; Phospholipids - biosynthesis ; Stearic Acids - metabolism ; Stereoisomerism ; Triglycerides - biosynthesis ; Tritium</subject><ispartof>Biochemical journal, 1970-07, Vol.118 (3), p.433-442</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-e38aae3e0235802ac3a27075b0eff3e8e29279ab9a15a97c8675cd1585e342e73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1179210/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1179210/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5472169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bickerstaffe, R</creatorcontrib><creatorcontrib>Annison, E F</creatorcontrib><title>Lipid metabolism in the perfused chicken liver. The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>Comparative studies were made of the uptake and metabolism of cis- and trans-octadecenoic acids by the perfused chicken liver. No differences were observed in the rates of uptake of the isomers. There was considerable incorporation of radioactivity into triglycerides and phospholipids, and some release of labelled lipid into the perfusate was observed. The cis-fatty acids were more readily incorporated into triglycerides than phospholipids, the reverse being true of the trans-fatty acids. Examination of the intramolecular distribution of fatty acids in triglycerides showed that the trans-fatty acid and stearate mainly occupied the 1- and 3-positions, and cis-fatty acids the 2-position. In the phospholipids phosphatidylcholine and phosphatidylethanolamine the trans-fatty acids again behaved like stearic acid and favoured the 1-position. No evidence was obtained of atypical patterns of uptake or metabolism of the trans-fatty acids.</description><subject>Animals</subject><subject>Carbon Isotopes</subject><subject>Chickens</subject><subject>Chromatography, Gas</subject><subject>Fatty Acids - metabolism</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Methylation</subject><subject>Oleic Acids - metabolism</subject><subject>Perfusion</subject><subject>Phospholipids - biosynthesis</subject><subject>Stearic Acids - metabolism</subject><subject>Stereoisomerism</subject><subject>Triglycerides - biosynthesis</subject><subject>Tritium</subject><issn>0264-6021</issn><issn>0306-3283</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUU1LHUEQHCTBPI0Hf0BgTgHBNT0f-2b2EhDRJPDAizkPvbO9vtH9yszug_wZf6trfCzRU9NV1dUFxdipgAsBWn4rH4SwoJU6YCuhDWTWSPuBrUCudbYGKT6xo5QeAIQGDYfsMNdGinWxYk-bMISKtzRi2TchtTx0fNwSHyjWU6KK-23wj9TxJuwoXvC7mZuGER-JY_fmsK9531DwHH2ozjk1GKpl8yFlO_SeugUaI3bvwH-WaSSMe-Az-1hjk-hkP4_Z75vru6uf2eb2x6-ry03mlYExI2URSRFIlVuQ6BVKAyYvgepakSVZSFNgWaDIsTDerk3uK5HbnJSWZNQx-_7qO0xlS9WcaE7XuCGGFuNf12Nwb5kubN19v3NCmEIKmA2-7g1i_2eiNLo2JE9Ngx31U3J2bkVJLWbh2avQxz6lSPXyRIB7KdMtZc7aL_-nWpT79tQzq9icLA</recordid><startdate>19700701</startdate><enddate>19700701</enddate><creator>Bickerstaffe, R</creator><creator>Annison, E F</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19700701</creationdate><title>Lipid metabolism in the perfused chicken liver. 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The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1970-07-01</date><risdate>1970</risdate><volume>118</volume><issue>3</issue><spage>433</spage><epage>442</epage><pages>433-442</pages><issn>0264-6021</issn><issn>0306-3283</issn><eissn>1470-8728</eissn><abstract>Comparative studies were made of the uptake and metabolism of cis- and trans-octadecenoic acids by the perfused chicken liver. No differences were observed in the rates of uptake of the isomers. There was considerable incorporation of radioactivity into triglycerides and phospholipids, and some release of labelled lipid into the perfusate was observed. The cis-fatty acids were more readily incorporated into triglycerides than phospholipids, the reverse being true of the trans-fatty acids. Examination of the intramolecular distribution of fatty acids in triglycerides showed that the trans-fatty acid and stearate mainly occupied the 1- and 3-positions, and cis-fatty acids the 2-position. In the phospholipids phosphatidylcholine and phosphatidylethanolamine the trans-fatty acids again behaved like stearic acid and favoured the 1-position. No evidence was obtained of atypical patterns of uptake or metabolism of the trans-fatty acids.</abstract><cop>England</cop><pmid>5472169</pmid><doi>10.1042/bj1180433</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Biochemical journal, 1970-07, Vol.118 (3), p.433-442 |
| issn | 0264-6021 0306-3283 1470-8728 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Carbon Isotopes Chickens Chromatography, Gas Fatty Acids - metabolism In Vitro Techniques Liver - metabolism Methylation Oleic Acids - metabolism Perfusion Phospholipids - biosynthesis Stearic Acids - metabolism Stereoisomerism Triglycerides - biosynthesis Tritium |
| title | Lipid metabolism in the perfused chicken liver. The uptake and metabolism of oleic acid, elaidic acid, cis-vaccenic acid, trans-vaccenic acid and stearic acid |
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