Insights into interspecies protein binding variability using clindamycin as an example

In the preclinical development of new drugs, animal models are often employed to predict their efficacy in humans, relying on translational pharmacokinetic/pharmacodynamic (PK/PD) studies. We performed in vitro experiments focusing on the comparison of plasma protein binding (PPB) and bacterial grow...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2024-11, Vol.80 (2), p.363-371
Hauptverfasser:	Ahmed, Hifza, Böhmdorfer, Michaela, Jäger, Walter, Zeitlinger, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Blood Proteins - metabolism Cattle Clindamycin - pharmacokinetics Clindamycin - pharmacology Humans Microbial Sensitivity Tests Microbial Viability - drug effects Original Research Plasma - chemistry Protein Binding Rats Staphylococcus aureus - drug effects
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