Updates implemented in version 4 of the GlyCosmos Glycoscience Portal: Updates implemented in version 4 of the GlyCosmos Glycoscience Portal
Glycosylation, characterized by its complexity and diversity, is a common system across all domains of life. The glycosylation of proteins or lipids imparts them with structural and functional roles, ranging from development to infectious or Mendelian disease. The high-throughput-based omics data ha...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2025-02, Vol.417 (5), p.907-919 |
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| creator | Lee, Sunmyoung Ono, Tamiko Masaaki, Shiota Fujita, Akihiro Matsubara, Masaaki Zappa, Achille Yamada, Issaku Aoki-Kinoshita, Kiyoko F. |
| description | Glycosylation, characterized by its complexity and diversity, is a common system across all domains of life. The glycosylation of proteins or lipids imparts them with structural and functional roles, ranging from development to infectious or Mendelian disease. The high-throughput-based omics data has revealed that glycans are involved in important cellular processes. Comprehensive knowledge of glycosylation has contributed not only to the fundamental concepts in glycoscience but also to its applications, including the development of molecular markers for diagnosis and therapeutic tools for treating diseases. The GlyCosmos Glycoscience Portal (GlyCosmos) has undergone significant updates to better support the scientific community in studying glycosylation-related phenomena. Key enhancements include the integration of expanded datasets linking glycans to other omics fields, improved tools for glycan structure prediction and analysis, and upgraded visualization capabilities to streamline data interpretation. A strengthened focus on data standardization has also been introduced, fostering interoperability between glycoscience resources and external databases. Since its release in 2019, the portal has seen a fivefold increase in user engagement, reflecting its growing relevance. These recent advancements aim to provide researchers with a more comprehensive and user-friendly platform, enabling deeper insights into glycan roles in cellular processes and disease mechanisms. GlyCosmos will continue to evolve, prioritizing community needs and advancing the integration of glycoscience with broader biological and biomedical research.
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| doi_str_mv | 10.1007/s00216-024-05692-0 |
| format | Article |
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Graphical Abstract</description><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Biological activity</subject><subject>Cellular structure</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Communication</subject><subject>Current Progress in Glycosciences and Glycobioinformatics</subject><subject>Data interpretation</subject><subject>Databases, Factual</subject><subject>Food Science</subject><subject>Glycan</subject><subject>Glycomics - methods</subject><subject>Glycosylation</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Lipid rafts</subject><subject>Lipids</subject><subject>Medical research</subject><subject>Medical treatment</subject><subject>Monitoring/Environmental Analysis</subject><subject>Polysaccharides</subject><subject>Polysaccharides - analysis</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - metabolism</subject><subject>Structure-function relationships</subject><issn>1618-2642</issn><issn>1618-2650</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAQhq2qqLvQ_gEOVaReegmdsR3HOSG0Wj4kpHIoZ8txJhCUxIudRdp_Xy9Ll8KB04xmnnlnRi9jxwgnCFD-igAcVQ5c5lCoiufwic1Roc65KuDzPpd8xg5jfADAQqP6wmaiUhUIFHO2vF01dqKYdcOqp4HGiZqsG7MnCrHzYyYz32bTPWUX_Wbh4-DjNnM-uo5GR9mND5Ptv7KD1vaRvr3EI3Z7vvyzuMyvf19cLc6ucyeQTzm2rRItkJSusoUFLZuy0aIQVIN2sm5TnWRdgCp5o1DUZW21VU43DhtUtThipzvd1boeqHHp3GB7swrdYMPGeNuZt52xuzd3_skglpoLLJPCzxeF4B_XFCczdNFR39uR_DoagVJVUqMUCf3xDn3w6zCm_xKlUIHiGhLFd5QLPsZA7f4aBLO1yexsMskm82yT2Q59__-P_cg_XxIgdkBMrfGOwuvuD2T_AsJPnaI</recordid><startdate>202502</startdate><enddate>202502</enddate><creator>Lee, Sunmyoung</creator><creator>Ono, Tamiko</creator><creator>Masaaki, Shiota</creator><creator>Fujita, Akihiro</creator><creator>Matsubara, Masaaki</creator><creator>Zappa, Achille</creator><creator>Yamada, Issaku</creator><creator>Aoki-Kinoshita, Kiyoko F.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202502</creationdate><title>Updates implemented in version 4 of the GlyCosmos Glycoscience Portal</title><author>Lee, Sunmyoung ; 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A strengthened focus on data standardization has also been introduced, fostering interoperability between glycoscience resources and external databases. Since its release in 2019, the portal has seen a fivefold increase in user engagement, reflecting its growing relevance. These recent advancements aim to provide researchers with a more comprehensive and user-friendly platform, enabling deeper insights into glycan roles in cellular processes and disease mechanisms. GlyCosmos will continue to evolve, prioritizing community needs and advancing the integration of glycoscience with broader biological and biomedical research.
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| subjects | Analytical Chemistry Biochemistry Biological activity Cellular structure Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Communication Current Progress in Glycosciences and Glycobioinformatics Data interpretation Databases, Factual Food Science Glycan Glycomics - methods Glycosylation Humans Laboratory Medicine Lipid rafts Lipids Medical research Medical treatment Monitoring/Environmental Analysis Polysaccharides Polysaccharides - analysis Polysaccharides - chemistry Polysaccharides - metabolism Structure-function relationships |
| title | Updates implemented in version 4 of the GlyCosmos Glycoscience Portal: Updates implemented in version 4 of the GlyCosmos Glycoscience Portal |
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