Leptin drives glucose metabolism to promote cardiac protection via OPA1-mediated HDAC5 translocation and Glut4 transcription

Metabolic reprogramming, the shifting from fatty acid oxidation to glucose utilization, improves cardiac function as heart failure (HF) progresses. Leptin plays an essential role in regulating glucose metabolism. However, the crosstalk between leptin and metabolic reprogramming is poorly understood....

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Veröffentlicht in:	Functional & integrative genomics 2025-12, Vol.25 (1), p.28, Article 28
Hauptverfasser:	Yang, Fan, He, Youfu, Zhao, Ling, Huang, Jing, Du, Fawang, Tian, Shui, Zhang, Yang, Liu, Xinghui, Chen, Baolin, Ge, Junhua, Jiang, Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Annexin V Apoptosis Biochemistry Bioinformatics Biomedical and Life Sciences Cardiac function Cell Biology Cell fusion Cell Line Cell survival Congestive heart failure Coronary artery Glucose Glucose - metabolism Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism Heart failure Heart Failure - genetics Heart Failure - metabolism Histone Deacetylases - genetics Histone Deacetylases - metabolism Ischemia Leptin Leptin - genetics Leptin - metabolism Life Sciences Male Metabolism Mice Mice, Inbred C57BL Microbial Genetics and Genomics Mitochondrial Dynamics - drug effects Myocardial infarction Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocyte enhancer factor 2 Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oxidation Plant Genetics and Genomics Rats RNA transport RNA-mediated interference Therapeutic targets
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