Palmatine Ameliorates Motor Deficits and Dopaminergic Neuron Loss by Regulating NLRP3 Inflammasome through Mitophagy in Parkinson's Disease Model Mice

NLRP3 inflammasomes-mediated proinflammatory response and mitochondrial dysfunction play a critical role in the etiology and pathogenesis of Parkinson's disease. Negative regulation of NLRP3 inflammasome activation through mitophagy may be an important strategy to control NLRP3 inflammasome-med...

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Veröffentlicht in:	Molecular neurobiology 2025-02, Vol.62 (2), p.2250-2263
Hauptverfasser:	Zhao, Jindong, Wang, Ji, Zhao, Kunying, Yang, Shuda, Dong, Junfang, Zhang, Yuxiao, Wu, Shangpeng, Xiang, Lirong, Hu, Weiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Berberine Alkaloids - pharmacology Berberine Alkaloids - therapeutic use Biomedical and Life Sciences Biomedicine Cell Biology Cell death Chloroquine Disease Models, Animal Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Inflammasomes Inflammasomes - drug effects Inflammasomes - metabolism Inflammation Male Mice Mice, Inbred C57BL Mitophagy Mitophagy - drug effects Motor Activity - drug effects Movement disorders MPTP Neurobiology Neurodegenerative diseases Neurology Neurosciences NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease
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