Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma
Background and Objectives Soft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous...
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| Veröffentlicht in: | Journal of surgical oncology 2024-09, Vol.130 (3), p.543-551 |
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| creator | Garibay, Eric Robles Cruz, Sylvia M. Judge, Sean J. Monjazeb, Arta M. Thorpe, Steven W. Murphy, William J. Lyu, Jing Chen, Shuai Bateni, Cyrus P. Canter, Robert J. |
| description | Background and Objectives
Soft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery.
Methods
We analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence‐free survival.
Results
Although BMI was closely correlated with VFA (r = 0.69, p |
| doi_str_mv | 10.1002/jso.27751 |
| format | Article |
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Soft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery.
Methods
We analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence‐free survival.
Results
Although BMI was closely correlated with VFA (r = 0.69, p < 0.0001) and SFA (r = 0.80, p < 0.0001), there was no significant association between high BMI, VFA or SFA, and worse oncologic outcomes.
Conclusions
Although VFA and SFA are strongly correlated with BMI, we did not observe BMI nor imaging metrics of fat composition to be associated with worse oncologic outcomes. Further research is needed to elucidate any links between body fat content and metabolic or immune factors governing oncologic outcomes in STS.</description><identifier>ISSN: 0022-4790</identifier><identifier>ISSN: 1096-9098</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.27751</identifier><identifier>PMID: 39402905</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Body Composition ; Body Mass Index ; Female ; Follow-Up Studies ; Humans ; Intra-Abdominal Fat - diagnostic imaging ; Intra-Abdominal Fat - pathology ; Male ; Middle Aged ; obesity ; Prognosis ; Retrospective Studies ; Sarcoma - diagnostic imaging ; Sarcoma - pathology ; Sarcoma - surgery ; soft tissue sarcoma ; Subcutaneous Fat - diagnostic imaging ; Subcutaneous Fat - pathology ; subcutaneous fat area ; Survival Rate ; Tomography, X-Ray Computed ; visceral fat area</subject><ispartof>Journal of surgical oncology, 2024-09, Vol.130 (3), p.543-551</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3691-52ffdb568e9f0d34ae527b31f9c8e158e7937537ede407f5775a03437b9251f43</cites><orcidid>0000-0001-9007-6639 ; 0000-0002-3331-5418</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.27751$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.27751$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39402905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garibay, Eric Robles</creatorcontrib><creatorcontrib>Cruz, Sylvia M.</creatorcontrib><creatorcontrib>Judge, Sean J.</creatorcontrib><creatorcontrib>Monjazeb, Arta M.</creatorcontrib><creatorcontrib>Thorpe, Steven W.</creatorcontrib><creatorcontrib>Murphy, William J.</creatorcontrib><creatorcontrib>Lyu, Jing</creatorcontrib><creatorcontrib>Chen, Shuai</creatorcontrib><creatorcontrib>Bateni, Cyrus P.</creatorcontrib><creatorcontrib>Canter, Robert J.</creatorcontrib><title>Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description>Background and Objectives
Soft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery.
Methods
We analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence‐free survival.
Results
Although BMI was closely correlated with VFA (r = 0.69, p < 0.0001) and SFA (r = 0.80, p < 0.0001), there was no significant association between high BMI, VFA or SFA, and worse oncologic outcomes.
Conclusions
Although VFA and SFA are strongly correlated with BMI, we did not observe BMI nor imaging metrics of fat composition to be associated with worse oncologic outcomes. Further research is needed to elucidate any links between body fat content and metabolic or immune factors governing oncologic outcomes in STS.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - diagnostic imaging</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>obesity</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sarcoma - diagnostic imaging</subject><subject>Sarcoma - pathology</subject><subject>Sarcoma - surgery</subject><subject>soft tissue sarcoma</subject><subject>Subcutaneous Fat - diagnostic imaging</subject><subject>Subcutaneous Fat - pathology</subject><subject>subcutaneous fat area</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><subject>visceral fat area</subject><issn>0022-4790</issn><issn>1096-9098</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq0KVJZtD_0DlSUucAjYcRzHpwqhfoCQOFC4Wk4ybr1K4q0nAe2_x0soAiROc3gfPZqZl5AvnB1zxvKTFYbjXCnJP5AFZ7rMNNPVDlmkLM8Kpdke2UdcMca0LouPZE_oguWayQWpbz02EG1HnR2pjWCpHVqKU91Mox0gTPgiQdqDxSkC0uBoHdoNbUK_DuhHHwbqB4rBjXT0iBNQtDGl9hPZdbZD-Pw0l-Tmx_ffZ7-yy6uf52enl1kjSs0zmTvX1rKsQDvWisKCzFUtuNNNBVxWoLRQUihooWDKyXSvZaIQqta55K4QS_Jt9q6nuoe2gWFMd5l19L2NGxOsN6-Twf81f8Kd4Tx5ecWS4fDJEMO_CXA0_fY7XTc_wgjOy1JJrVVCD96gqzDFId33SBVaykok6mimmhgQI7jnbTgz2-pMqs48VpfYry_Xfyb_d5WAkxm49x1s3jeZi-urWfkAmL-jpg</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Garibay, Eric Robles</creator><creator>Cruz, Sylvia M.</creator><creator>Judge, Sean J.</creator><creator>Monjazeb, Arta M.</creator><creator>Thorpe, Steven W.</creator><creator>Murphy, William J.</creator><creator>Lyu, Jing</creator><creator>Chen, Shuai</creator><creator>Bateni, Cyrus P.</creator><creator>Canter, Robert J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9007-6639</orcidid><orcidid>https://orcid.org/0000-0002-3331-5418</orcidid></search><sort><creationdate>202409</creationdate><title>Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma</title><author>Garibay, Eric Robles ; Cruz, Sylvia M. ; Judge, Sean J. ; Monjazeb, Arta M. ; Thorpe, Steven W. ; Murphy, William J. ; Lyu, Jing ; Chen, Shuai ; Bateni, Cyrus P. ; Canter, Robert J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3691-52ffdb568e9f0d34ae527b31f9c8e158e7937537ede407f5775a03437b9251f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - diagnostic imaging</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>obesity</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sarcoma - diagnostic imaging</topic><topic>Sarcoma - pathology</topic><topic>Sarcoma - surgery</topic><topic>soft tissue sarcoma</topic><topic>Subcutaneous Fat - diagnostic imaging</topic><topic>Subcutaneous Fat - pathology</topic><topic>subcutaneous fat area</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed</topic><topic>visceral fat area</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garibay, Eric Robles</creatorcontrib><creatorcontrib>Cruz, Sylvia M.</creatorcontrib><creatorcontrib>Judge, Sean J.</creatorcontrib><creatorcontrib>Monjazeb, Arta M.</creatorcontrib><creatorcontrib>Thorpe, Steven W.</creatorcontrib><creatorcontrib>Murphy, William J.</creatorcontrib><creatorcontrib>Lyu, Jing</creatorcontrib><creatorcontrib>Chen, Shuai</creatorcontrib><creatorcontrib>Bateni, Cyrus P.</creatorcontrib><creatorcontrib>Canter, Robert J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garibay, Eric Robles</au><au>Cruz, Sylvia M.</au><au>Judge, Sean J.</au><au>Monjazeb, Arta M.</au><au>Thorpe, Steven W.</au><au>Murphy, William J.</au><au>Lyu, Jing</au><au>Chen, Shuai</au><au>Bateni, Cyrus P.</au><au>Canter, Robert J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2024-09</date><risdate>2024</risdate><volume>130</volume><issue>3</issue><spage>543</spage><epage>551</epage><pages>543-551</pages><issn>0022-4790</issn><issn>1096-9098</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Soft tissue sarcomas (STS) are a heterogenous group of malignancies of mesenchymal origin. Given recent data linking obesity as well as the pattern of fat distribution with cancer outcomes, we sought to investigate the association of visceral fat area (VFA) and subcutaneous fat area (SFA) with oncologic outcomes in patients with STS undergoing surgery.
Methods
We analyzed data from 88 patients with STS diagnosed from 2008 to 2022. Predictor variables included body mass index (BMI), VFA, and SFA. VFA and SFA were obtained from computed tomography of the abdomen and pelvis. Univariable and multivariable Cox regression analysis was used to analyze associations between predictor variables and overall survival and recurrence‐free survival.
Results
Although BMI was closely correlated with VFA (r = 0.69, p < 0.0001) and SFA (r = 0.80, p < 0.0001), there was no significant association between high BMI, VFA or SFA, and worse oncologic outcomes.
Conclusions
Although VFA and SFA are strongly correlated with BMI, we did not observe BMI nor imaging metrics of fat composition to be associated with worse oncologic outcomes. Further research is needed to elucidate any links between body fat content and metabolic or immune factors governing oncologic outcomes in STS.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39402905</pmid><doi>10.1002/jso.27751</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9007-6639</orcidid><orcidid>https://orcid.org/0000-0002-3331-5418</orcidid></addata></record> |
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| ispartof | Journal of surgical oncology, 2024-09, Vol.130 (3), p.543-551 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Aged, 80 and over Body Composition Body Mass Index Female Follow-Up Studies Humans Intra-Abdominal Fat - diagnostic imaging Intra-Abdominal Fat - pathology Male Middle Aged obesity Prognosis Retrospective Studies Sarcoma - diagnostic imaging Sarcoma - pathology Sarcoma - surgery soft tissue sarcoma Subcutaneous Fat - diagnostic imaging Subcutaneous Fat - pathology subcutaneous fat area Survival Rate Tomography, X-Ray Computed visceral fat area |
| title | Visceral fat area and subcutaneous fat area as measures of body composition in soft tissue sarcoma |
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