Thiol-disulphide interchange in tubulin: kinetics and the effect on polymerization

All 20 cysteine residues are accessible to disulphide reagents in the tubulin dimer, whereas only four are accessible in taxol-stabilized microtubules. Reaction rates with disulphide reagents are a function of the reagent, are decreased by G nucleotides, and increased with increase in pH and urea. W...

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Veröffentlicht in:	Biochemical journal 2005-07, Vol.389 (Pt 2), p.549-558
Hauptverfasser:	Britto, P J, Knipling, Leslie, McPhie, Peter, Wolff, J
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - chemistry Adenosine Triphosphate - metabolism Amino Acid Sequence Biopolymers - chemistry Biopolymers - metabolism Cysteine - chemistry Cysteine - metabolism Disulfides - chemistry Disulfides - metabolism Dithionitrobenzoic Acid - chemistry Guanosine Diphosphate - metabolism Guanosine Triphosphate - metabolism Kinetics Methyl Methanesulfonate - analogs & derivatives Methyl Methanesulfonate - chemistry Molecular Structure Nitrobenzoates - chemistry Protein Denaturation Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - metabolism Tubulin - chemistry Tubulin - metabolism
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