Endothelial Expression of Constitutively Active Notch4 Elicits Reversible Arteriovenous Malformations in Adult Mice

Direct communication between arteries and veins without intervening capillary beds is the primary pathology of arteriovenous malformations (AVMs). Although Notch signaling is implicated in embryonic arteriovenous (AV) differentiation, its function in the adult mammalian vasculature has not been esta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-07, Vol.102 (28), p.9884-9889
Hauptverfasser:	Carlson, Timothy R., Yan, Yibing, Wu, Xiaoqing, Lam, Michael T., Tang, Gale L., Beverly, Levi J., Messina, Louis M., Capobianco, Anthony J., Werb, Zena, Wang, Rong, Bourne, Henry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteries Arteriovenous malformations Arteriovenous Malformations - complications Arteriovenous Malformations - genetics Arteriovenous Malformations - pathology Biological Sciences Blood vessels Cardiomegaly - etiology Echocardiography Endothelium, Vascular - metabolism Ephrin-B2 - metabolism Female Fluorescence Gene Expression Profiling Gene Expression Regulation - genetics Hepatic artery Histology Liver Liver - blood supply Liver - pathology Mice Microspheres Portal vein Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor, Notch4 Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Notch Respiratory system Rodents Signal transduction Signal Transduction - genetics Skin - blood supply Skin - pathology Tetracycline Transgenes Uterus Uterus - blood supply Uterus - pathology Veins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!