Medical genetics: 1. Clinical teratology in the age of genomics

Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogen...

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Veröffentlicht in:	Canadian Medical Association journal 2002-08, Vol.167 (3), p.265-273
Hauptverfasser:	Polifka, Janine E, Friedman, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alcohol Drinking - adverse effects Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Congenital diseases Drugs Environmental Exposure Epilepsy - drug therapy Female Genetic Counseling Genetic Predisposition to Disease Genetic Testing Genetics Genetics, Medical - trends Humans Physiological aspects Pregnancy Review Risk Assessment Smoking - adverse effects Teratogens - toxicity Toxic chemicals Valproic Acid - adverse effects Valproic Acid - therapeutic use
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