Medical genetics: 1. Clinical teratology in the age of genomics
Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogen...
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| Veröffentlicht in: | Canadian Medical Association journal 2002-08, Vol.167 (3), p.265-273 |
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| container_title | Canadian Medical Association journal |
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| creator | Polifka, Janine E Friedman, J.M |
| description | Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogenesis, as well as known genetic susceptibilities to teratogenic effects, with a special focus on antiepileptic drugs. We discuss general principles of risk counselling and risk reduction, and we describe several long-known teratogens, as well as several exposures recognized only recently to have teratogenic potential. |
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Clinical teratology in the age of genomics</atitle><jtitle>Canadian Medical Association journal</jtitle><addtitle>CMAJ</addtitle><date>2002-08-06</date><risdate>2002</risdate><volume>167</volume><issue>3</issue><spage>265</spage><epage>273</epage><pages>265-273</pages><issn>0008-4409</issn><issn>0820-3946</issn><eissn>1488-2329</eissn><coden>CMAJAX</coden><abstract>Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogenesis, as well as known genetic susceptibilities to teratogenic effects, with a special focus on antiepileptic drugs. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Alcohol Drinking - adverse effects Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Congenital diseases Drugs Environmental Exposure Epilepsy - drug therapy Female Genetic Counseling Genetic Predisposition to Disease Genetic Testing Genetics Genetics, Medical - trends Humans Physiological aspects Pregnancy Review Risk Assessment Smoking - adverse effects Teratogens - toxicity Toxic chemicals Valproic Acid - adverse effects Valproic Acid - therapeutic use |
| title | Medical genetics: 1. Clinical teratology in the age of genomics |
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