DesiRNA: structure-based design of RNA sequences with a replica exchange Monte Carlo approach

Designing RNA sequences that form a specific structure remains a challenge. Current computational methods often struggle with the complexity of RNA structures, especially when considering pseudoknots or restrictions related to RNA function. We developed DesiRNA, a computational tool for the design o...

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Veröffentlicht in:	Nucleic acids research 2025-01, Vol.53 (2)
Hauptverfasser:	Wirecki, Tomasz K, Lach, Grzegorz, Badepally, Nagendar Goud, Moafinejad, S Naeim, Jaryani, Farhang, Klaudel, Gaja, Nec, Kalina, Baulin, Eugene F, Bujnicki, Janusz M
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Base Sequence Computational Biology - methods Methods Monte Carlo Method Nucleic Acid Conformation RNA - chemistry RNA Folding Sequence Analysis, RNA - methods Software
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