Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective

Physiologically‐based pharmacokinetic (PBPK) modeling offers a viable approach to predict induction drug–drug interactions (DDIs) with the potential to streamline or reduce clinical trial burden if predictions can be made with sufficient confidence. In the current work, the ability to predict the ef...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2025-02, Vol.117 (2), p.403-420
Hauptverfasser:	Reddy, Micaela B., Cabalu, Tamara D., Zwart, Loeckie, Ramsden, Diane, Dowty, Martin E., Taskar, Kunal S., Badée, Justine, Bolleddula, Jayaprakasam, Boulu, Laurent, Fu, Qiang, Kotsuma, Masakatsu, Leblanc, Alix F., Lewis, Gareth, Liang, Guiqing, Parrott, Neil, Pilla Reddy, Venkatesh, Prakash, Chandra, Shah, Kushal, Umehara, Kenichi, Mukherjee, Dwaipayan, Rehmel, Jessica, Hariparsad, Niresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inducers - pharmacology Drug Industry Drug Interactions Humans Liver - metabolism Models, Biological Review Rifampin - pharmacokinetics Rifampin - pharmacology Systematic Review
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