Deep brain stimulation of the anterior cingulate cortex reduces opioid addiction in preclinical studies

Substance Use Disorder (SUD) is a medical condition where an individual compulsively misuses drugs or alcohol despite knowing the negative consequences. The anterior cingulate cortex (ACC) has been implicated in various types of SUDs, including nicotine, heroin, and alcohol use disorders. Our resear...

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Veröffentlicht in:	Scientific reports 2025-01, Vol.15 (1), p.2065-13, Article 2065
Hauptverfasser:	Fatemizadeh, Mahdi, Riahi, Esmail, Hassanzadeh, Gholamreza, Torkaman-Boutorabi, Anahita, Radfar, Forough, Farahmandfar, Maryam
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1788 631/443/376 Addiction Animals Anterior cingulate cortex c-Fos protein Cortex (cingulate) Deep brain stimulation Deep Brain Stimulation - methods Drug abuse Drug addiction Extinction behavior Fos protein Gyrus Cinguli - drug effects Gyrus Cinguli - metabolism Gyrus Cinguli - physiopathology Heroin Humanities and Social Sciences Locomotor activity Male Morphine Morphine - pharmacology multidisciplinary Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Open-field behavior Opioid-Related Disorders - metabolism Opioid-Related Disorders - therapy Place preference conditioning Prefrontal cortex Prefrontal Cortex - metabolism Protein expression Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Reinstatement Reward Science Science (multidisciplinary) Substance use
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