A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease
Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating α-synuclein aggregates and restoring degenerated dopamine n...
Gespeichert in:
| Veröffentlicht in: | Science advances 2025-01, Vol.11 (3), p.eado4927 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | eado4927 |
| container_title | Science advances |
| container_volume | 11 |
| creator | Wu, Junguang Cui, Xuejing Bao, Lin Liu, Guanyu Wang, Xiaoyu Chen, Chunying |
| description | Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating α-synuclein aggregates and restoring degenerated dopamine neurons in the substantia nigra to treat Parkinson's disease. This nanosystem (ATB NPs) consists of gold nanoshell, an antibody against the heat-sensitive transient receptor potential vanilloid family member 1 (TRPV1), and β-synuclein (β-syn) peptides with a near infrared-responsive linker. ATB NPs by stereotactic injection target dopamine neurons expressing TRPV1 receptors in the substantia nigra. Upon pulsed near-infrared irradiation, ATB NPs, serving as nanoantennae, convert the light into heat, leading to calcium ion influx, depolarization, and action potentials in dopamine neurons through TRPV1 receptors. Simultaneously, β-synuclein peptides released from ATB NPs cooperate with chaperone-mediated autophagy initiated by heat shock protein, HSC70, to effectively eliminate α-synuclein fibrils in neurons. These orchestrated actions restored pathological dopamine neurons and locomotor behaviors of Parkinson's disease. |
| doi_str_mv | 10.1126/sciadv.ado4927 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11734722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3156525822</sourcerecordid><originalsourceid>FETCH-LOGICAL-c236t-b16c5087f85c41f81c074c6202e0f0834728d1a77df2ead161dc0491689fc1623</originalsourceid><addsrcrecordid>eNpVkc1rGzEQxUVoSIyTa49lb-1lHY20q9WeijH5gkB6aI9FyNJso3Z35Wpkh_z3tWMnuKd5MO_9ZuAx9hH4DECoK3LB-s3M-li1ojlhEyGbuhR1pT8c6XN2SfSbcw6VUjW0Z-xcthqklHzCfs6L0Y5xZVMOrsdyaQl98RwS9khUeMRVsUw2jAXlMKx7m0Pc6hfKOBT5yeYi4QYTIRXfbPoTRorj520uEG5JF-y0sz3h5WFO2Y-b6--Lu_Lh8fZ-MX8onZAql0tQrua66XTtKug0ON5UTgkukHdcy6oR2oNtGt8JtB4UeMerFpRuOwdKyCn7uueu1ssBvcMxJ9ubVQqDTS8m2mD-34zhyfyKGwPQ7Og7wpcDIcW_a6RshkAO-96OGNdkJNSqFrV-tc72VpciUcLu_Q5ws-vF7Hsxh162gU_H373b31qQ_wBPcIzb</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3156525822</pqid></control><display><type>article</type><title>A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Wu, Junguang ; Cui, Xuejing ; Bao, Lin ; Liu, Guanyu ; Wang, Xiaoyu ; Chen, Chunying</creator><creatorcontrib>Wu, Junguang ; Cui, Xuejing ; Bao, Lin ; Liu, Guanyu ; Wang, Xiaoyu ; Chen, Chunying</creatorcontrib><description>Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating α-synuclein aggregates and restoring degenerated dopamine neurons in the substantia nigra to treat Parkinson's disease. This nanosystem (ATB NPs) consists of gold nanoshell, an antibody against the heat-sensitive transient receptor potential vanilloid family member 1 (TRPV1), and β-synuclein (β-syn) peptides with a near infrared-responsive linker. ATB NPs by stereotactic injection target dopamine neurons expressing TRPV1 receptors in the substantia nigra. Upon pulsed near-infrared irradiation, ATB NPs, serving as nanoantennae, convert the light into heat, leading to calcium ion influx, depolarization, and action potentials in dopamine neurons through TRPV1 receptors. Simultaneously, β-synuclein peptides released from ATB NPs cooperate with chaperone-mediated autophagy initiated by heat shock protein, HSC70, to effectively eliminate α-synuclein fibrils in neurons. These orchestrated actions restored pathological dopamine neurons and locomotor behaviors of Parkinson's disease.</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.ado4927</identifier><identifier>PMID: 39813330</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>alpha-Synuclein - metabolism ; Animals ; Biomedicine and Life Sciences ; Deep Brain Stimulation - methods ; Disease Models, Animal ; Dopaminergic Neurons - metabolism ; Gold - chemistry ; Humans ; Materials Science ; Mice ; Nanoparticles - chemistry ; Neuroscience ; Parkinson Disease - metabolism ; Parkinson Disease - pathology ; Parkinson Disease - therapy ; SciAdv r-articles ; Substantia Nigra - metabolism ; TRPV Cation Channels - metabolism ; Wireless Technology</subject><ispartof>Science advances, 2025-01, Vol.11 (3), p.eado4927</ispartof><rights>Copyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2025 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c236t-b16c5087f85c41f81c074c6202e0f0834728d1a77df2ead161dc0491689fc1623</cites><orcidid>0000-0002-9666-6549 ; 0009-0003-4568-213X ; 0000-0003-1894-0589 ; 0000-0002-6027-0315 ; 0000-0003-0842-3967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734722/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734722/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39813330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Junguang</creatorcontrib><creatorcontrib>Cui, Xuejing</creatorcontrib><creatorcontrib>Bao, Lin</creatorcontrib><creatorcontrib>Liu, Guanyu</creatorcontrib><creatorcontrib>Wang, Xiaoyu</creatorcontrib><creatorcontrib>Chen, Chunying</creatorcontrib><title>A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease</title><title>Science advances</title><addtitle>Sci Adv</addtitle><description>Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating α-synuclein aggregates and restoring degenerated dopamine neurons in the substantia nigra to treat Parkinson's disease. This nanosystem (ATB NPs) consists of gold nanoshell, an antibody against the heat-sensitive transient receptor potential vanilloid family member 1 (TRPV1), and β-synuclein (β-syn) peptides with a near infrared-responsive linker. ATB NPs by stereotactic injection target dopamine neurons expressing TRPV1 receptors in the substantia nigra. Upon pulsed near-infrared irradiation, ATB NPs, serving as nanoantennae, convert the light into heat, leading to calcium ion influx, depolarization, and action potentials in dopamine neurons through TRPV1 receptors. Simultaneously, β-synuclein peptides released from ATB NPs cooperate with chaperone-mediated autophagy initiated by heat shock protein, HSC70, to effectively eliminate α-synuclein fibrils in neurons. These orchestrated actions restored pathological dopamine neurons and locomotor behaviors of Parkinson's disease.</description><subject>alpha-Synuclein - metabolism</subject><subject>Animals</subject><subject>Biomedicine and Life Sciences</subject><subject>Deep Brain Stimulation - methods</subject><subject>Disease Models, Animal</subject><subject>Dopaminergic Neurons - metabolism</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Materials Science</subject><subject>Mice</subject><subject>Nanoparticles - chemistry</subject><subject>Neuroscience</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - therapy</subject><subject>SciAdv r-articles</subject><subject>Substantia Nigra - metabolism</subject><subject>TRPV Cation Channels - metabolism</subject><subject>Wireless Technology</subject><issn>2375-2548</issn><issn>2375-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1rGzEQxUVoSIyTa49lb-1lHY20q9WeijH5gkB6aI9FyNJso3Z35Wpkh_z3tWMnuKd5MO_9ZuAx9hH4DECoK3LB-s3M-li1ojlhEyGbuhR1pT8c6XN2SfSbcw6VUjW0Z-xcthqklHzCfs6L0Y5xZVMOrsdyaQl98RwS9khUeMRVsUw2jAXlMKx7m0Pc6hfKOBT5yeYi4QYTIRXfbPoTRorj520uEG5JF-y0sz3h5WFO2Y-b6--Lu_Lh8fZ-MX8onZAql0tQrua66XTtKug0ON5UTgkukHdcy6oR2oNtGt8JtB4UeMerFpRuOwdKyCn7uueu1ssBvcMxJ9ubVQqDTS8m2mD-34zhyfyKGwPQ7Og7wpcDIcW_a6RshkAO-96OGNdkJNSqFrV-tc72VpciUcLu_Q5ws-vF7Hsxh162gU_H373b31qQ_wBPcIzb</recordid><startdate>20250117</startdate><enddate>20250117</enddate><creator>Wu, Junguang</creator><creator>Cui, Xuejing</creator><creator>Bao, Lin</creator><creator>Liu, Guanyu</creator><creator>Wang, Xiaoyu</creator><creator>Chen, Chunying</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9666-6549</orcidid><orcidid>https://orcid.org/0009-0003-4568-213X</orcidid><orcidid>https://orcid.org/0000-0003-1894-0589</orcidid><orcidid>https://orcid.org/0000-0002-6027-0315</orcidid><orcidid>https://orcid.org/0000-0003-0842-3967</orcidid></search><sort><creationdate>20250117</creationdate><title>A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease</title><author>Wu, Junguang ; Cui, Xuejing ; Bao, Lin ; Liu, Guanyu ; Wang, Xiaoyu ; Chen, Chunying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c236t-b16c5087f85c41f81c074c6202e0f0834728d1a77df2ead161dc0491689fc1623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>alpha-Synuclein - metabolism</topic><topic>Animals</topic><topic>Biomedicine and Life Sciences</topic><topic>Deep Brain Stimulation - methods</topic><topic>Disease Models, Animal</topic><topic>Dopaminergic Neurons - metabolism</topic><topic>Gold - chemistry</topic><topic>Humans</topic><topic>Materials Science</topic><topic>Mice</topic><topic>Nanoparticles - chemistry</topic><topic>Neuroscience</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - therapy</topic><topic>SciAdv r-articles</topic><topic>Substantia Nigra - metabolism</topic><topic>TRPV Cation Channels - metabolism</topic><topic>Wireless Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Junguang</creatorcontrib><creatorcontrib>Cui, Xuejing</creatorcontrib><creatorcontrib>Bao, Lin</creatorcontrib><creatorcontrib>Liu, Guanyu</creatorcontrib><creatorcontrib>Wang, Xiaoyu</creatorcontrib><creatorcontrib>Chen, Chunying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Junguang</au><au>Cui, Xuejing</au><au>Bao, Lin</au><au>Liu, Guanyu</au><au>Wang, Xiaoyu</au><au>Chen, Chunying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease</atitle><jtitle>Science advances</jtitle><addtitle>Sci Adv</addtitle><date>2025-01-17</date><risdate>2025</risdate><volume>11</volume><issue>3</issue><spage>eado4927</spage><pages>eado4927-</pages><issn>2375-2548</issn><eissn>2375-2548</eissn><abstract>Deep brain stimulation technology enables the neural modulation with precise spatial control but requires permanent implantation of conduits. Here, we describe a photothermal wireless deep brain stimulation nanosystem capable of eliminating α-synuclein aggregates and restoring degenerated dopamine neurons in the substantia nigra to treat Parkinson's disease. This nanosystem (ATB NPs) consists of gold nanoshell, an antibody against the heat-sensitive transient receptor potential vanilloid family member 1 (TRPV1), and β-synuclein (β-syn) peptides with a near infrared-responsive linker. ATB NPs by stereotactic injection target dopamine neurons expressing TRPV1 receptors in the substantia nigra. Upon pulsed near-infrared irradiation, ATB NPs, serving as nanoantennae, convert the light into heat, leading to calcium ion influx, depolarization, and action potentials in dopamine neurons through TRPV1 receptors. Simultaneously, β-synuclein peptides released from ATB NPs cooperate with chaperone-mediated autophagy initiated by heat shock protein, HSC70, to effectively eliminate α-synuclein fibrils in neurons. These orchestrated actions restored pathological dopamine neurons and locomotor behaviors of Parkinson's disease.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>39813330</pmid><doi>10.1126/sciadv.ado4927</doi><orcidid>https://orcid.org/0000-0002-9666-6549</orcidid><orcidid>https://orcid.org/0009-0003-4568-213X</orcidid><orcidid>https://orcid.org/0000-0003-1894-0589</orcidid><orcidid>https://orcid.org/0000-0002-6027-0315</orcidid><orcidid>https://orcid.org/0000-0003-0842-3967</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2375-2548 |
| ispartof | Science advances, 2025-01, Vol.11 (3), p.eado4927 |
| issn | 2375-2548 2375-2548 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11734722 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | alpha-Synuclein - metabolism Animals Biomedicine and Life Sciences Deep Brain Stimulation - methods Disease Models, Animal Dopaminergic Neurons - metabolism Gold - chemistry Humans Materials Science Mice Nanoparticles - chemistry Neuroscience Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - therapy SciAdv r-articles Substantia Nigra - metabolism TRPV Cation Channels - metabolism Wireless Technology |
| title | A nanoparticle-based wireless deep brain stimulation system that reverses Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T09%3A22%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20nanoparticle-based%20wireless%20deep%20brain%20stimulation%20system%20that%20reverses%20Parkinson's%20disease&rft.jtitle=Science%20advances&rft.au=Wu,%20Junguang&rft.date=2025-01-17&rft.volume=11&rft.issue=3&rft.spage=eado4927&rft.pages=eado4927-&rft.issn=2375-2548&rft.eissn=2375-2548&rft_id=info:doi/10.1126/sciadv.ado4927&rft_dat=%3Cproquest_pubme%3E3156525822%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3156525822&rft_id=info:pmid/39813330&rfr_iscdi=true |