Development of a recombinant Ang1 variant with enhanced Tie2 binding and its application to attenuate sepsis in mice

The angiopoietin (Ang)-Tie axis, critical for endothelial cell function and vascular development, is a promising therapeutic target for treating vascular disorders and inflammatory conditions like sepsis. This study aimed to enhance the binding affinity of recombinant Ang1 variants to the Tie2 and e...

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