Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia

Acute myeloid leukemia (AML) featuring retinoic acid receptor-gamma (RARG) rearrangements exhibits morphological features resembling those of acute promyelocytic leukemia but is associated with drug resistance and poor clinical outcomes. However, the mechanisms underlying the role of RARG fusions in...

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Veröffentlicht in:	Nature communications 2025-01, Vol.16 (1), p.617, Article 617
Hauptverfasser:	Wang, Feng, Zhao, Luyao, Tan, Yun, Cen, Xufeng, Gao, Huan, Jiang, Huimin, Liu, Ying, Li, Yunxuan, Zhang, Tingting, Zhao, Chenxi, Shi, Ting, Xu, Guilin, Wang, Churan, Hu, Jiong, Li, Xia, Qin, Ya-Zhen, Wang, Kankan, Zhu, Hong-Hu, Li, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/2 13/31 38/23 38/91 631/67/1990/283/1897 631/80/304 692/699/1541/1990/283/1897 Acid resistance Activating transcription factor 3 Acute myeloid leukemia Acute promyeloid leukemia Bcl-2 protein Cell differentiation Cell proliferation Cell self-renewal Cells (biology) Daunorubicin Drug resistance Hematopoietic stem cells Hemopoiesis High-throughput screening Humanities and Social Sciences Leukemia Leukemogenesis Molecular modelling multidisciplinary Myc protein Phenotypes Progenitor cells Promyeloid leukemia Receptors Retinoic acid Retinoic acid receptors Science Science (multidisciplinary) Therapeutic targets
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