Autopsy case of meningoencephalitis induced by nivolumab and ipilimumab in a patient being treated for non-small cell lung cancer

A 75-year-old woman with stage IVB (cT2bN3M1b) lung adenocarcinoma was administered nivolumab, ipilimumab, carboplatin, and paclitaxel. Fourteen days after receiving chemotherapy, she experienced an impaired consciousness and a cerebrospinal fluid analysis revealed high protein levels and pleocytosi...

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Veröffentlicht in:	Internal Medicine 2024, pp.3457-24
Hauptverfasser:	Shiraha, Keisuke, Watanabe, Hiromi, Fujiwara, Keiichi, Goda, Mayu, Inoue, Tomoyoshi, Fujiwara, Miho, Matsuoka, Suzuka, Takigawa, Yuki, Mitsumune, Sho, Kudo, Kenichiro, Sato, Akiko, Sato, Ken, Shinno, Yoko, Shibayama, Takuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Autopsy Blood vessels Carboplatin Carcinoma, Non-Small-Cell Lung - drug therapy Case Report CD8 antigen Cerebrospinal fluid Chemotherapy Consciousness Corticosteroids Encephalitis Fatal Outcome Female Humans immune checkpoint inhibitor ipilimumab Ipilimumab - adverse effects Lung Neoplasms - drug therapy Lymphocytes Meningoencephalitis Meningoencephalitis - chemically induced nivolumab Nivolumab - adverse effects Non-small cell lung carcinoma Paclitaxel Pleocytosis Small cell lung carcinoma
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