Substrate‐Multiplexed Assessment of Aromatic Prenyltransferase Activity

An increasingly effective strategy to identify synthetically useful enzymes is to sample the diversity already present in Nature. Here, we construct and assay a panel of phylogenetically diverse aromatic prenyltransferases (PTs). These enzymes catalyze a variety of C−C bond forming reactions in natu...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2025-01, Vol.26 (1), p.e202400680-n/a
Hauptverfasser:	Higgins, Peyton M., Wehrli, Nicolette G., Buller, Andrew R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Biosynthesis Chemical bonds Chemical reactions Dimethylallyltranstransferase - chemistry Dimethylallyltranstransferase - metabolism Enzyme Promiscuity Enzymes Multiplexed Screening Multiplexing Natural products Prenyltransferases Screening Sequence-similarity Network Substrate Scope Substrate Specificity
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