Stereo-Differentiating Asymmetric Rh(I)-Catalyzed Pauson–Khand Reaction: A DFT-Informed Approach to Thapsigargin Stereoisomers

We report a stereo-differentiating dynamic kinetic asymmetric Rh­(I)-catalyzed Pauson–Khand reaction, which provides access to an array of thapsigargin stereoisomers. Using catalyst-control, a consistent stereochemical outcome is achieved at C2for both matched and mismatched casesregardless of the...

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Veröffentlicht in:	Journal of the American Chemical Society 2025-01, Vol.147 (1), p.498-509
Hauptverfasser:	Haghighi, Fatemeh, Jesikiewicz, Luke T., Stahl, Corrinne E., Nafie, Jordan, Ortega-Vega, Amanda, Liu, Peng, Brummond, Kay M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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