B Lymphocyte—A Prognostic Indicator in Post‐Acute Pancreatitis Diabetes Mellitus
ABSTRACT Objective To determine the value of lymphocyte subsets and granulocyte/monocyte surface markers in predicting the risk of post‐acute pancreatitis diabetes (PPDM‐A). Methods This study included 308 in patients with acute pancreatitis (AP). The markers of granulocytes and monocytes and lympho...
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| creator | Lin, Xiaoyan Li, Xiaoling Wang, Junsheng Liu, Huiheng |
| description | ABSTRACT
Objective
To determine the value of lymphocyte subsets and granulocyte/monocyte surface markers in predicting the risk of post‐acute pancreatitis diabetes (PPDM‐A).
Methods
This study included 308 in patients with acute pancreatitis (AP). The markers of granulocytes and monocytes and lymphocyte subsets were detected by flow cytometry, and the fluorescence intensity, absolute count and percentage were obtained. Based on the occurrence of diabetes after AP, patients were divided into two groups: PPDM‐A and PPNG‐A (post‐acute pancreatitis with normal glucose). Correlations between granulocyte and monocyte surface markers and lymphocyte subsets were analyzed. Binary logistic regression was used to analyze the potential influencing factors of PPDM‐A.
Results
Compared with patients with PPNG‐A, patients with PPDM‐A tend to be younger (p |
| doi_str_mv | 10.1111/1753-0407.70047 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11725652</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3160213942</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3037-65236c0f8c5aa06d37a657bd03ff56f40309a9b58522060de19ef74affc4c8503</originalsourceid><addsrcrecordid>eNqFkb1u2zAUhYmgRX6czN0KAV2y2L4URVKaCuevdeEiHpKZoCnSZiCLDkkl8JZHyJAnzJNEqh2jzVIuJO79eO49OAh9wTDA7RliTkkfMuADDpDxPXS4q3x6f5OCHKCjEO4AGGeM7KMDUuSAMcsO0c1ZMlkvVwun1lG_Pr2Mkql389qFaFUyrkurZHQ-sXUybWuvT88j1USdTGWtvJbRRhuSCytnOuqQ_NZVZWMTjtFnI6ugT7Z3D91eXd6c_-xPrn-Mz0eTviJAeJ_RlDAFJldUSmAl4ZJRPiuBGEOZyYBAIYsZzWmaAoNS40IbnkljVKZyCqSHvm90V81sqUul6-hlJVbeLqVfCyet-LdT24WYuweBMU9pN76HTrcK3t03OkSxtEG1NmStXRMEwTTL84ICb9FvH9A71_i69ddSDFJMiqwTHG4o5V0IXpvdNhhEF5noQhFdQOJPZO2Pr3-b2PHvGbUA3QCPttLr_-mJXxdnG-E3dfuiAg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3160213942</pqid></control><display><type>article</type><title>B Lymphocyte—A Prognostic Indicator in Post‐Acute Pancreatitis Diabetes Mellitus</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Lin, Xiaoyan ; Li, Xiaoling ; Wang, Junsheng ; Liu, Huiheng</creator><creatorcontrib>Lin, Xiaoyan ; Li, Xiaoling ; Wang, Junsheng ; Liu, Huiheng</creatorcontrib><description>ABSTRACT
Objective
To determine the value of lymphocyte subsets and granulocyte/monocyte surface markers in predicting the risk of post‐acute pancreatitis diabetes (PPDM‐A).
Methods
This study included 308 in patients with acute pancreatitis (AP). The markers of granulocytes and monocytes and lymphocyte subsets were detected by flow cytometry, and the fluorescence intensity, absolute count and percentage were obtained. Based on the occurrence of diabetes after AP, patients were divided into two groups: PPDM‐A and PPNG‐A (post‐acute pancreatitis with normal glucose). Correlations between granulocyte and monocyte surface markers and lymphocyte subsets were analyzed. Binary logistic regression was used to analyze the potential influencing factors of PPDM‐A.
Results
Compared with patients with PPNG‐A, patients with PPDM‐A tend to be younger (p < 0.001) and have a higher proportion of fatty liver, recurrent pancreatitis, and hyperlipidemic pancreatitis. The results of linear regression showed that B% was negatively correlated with MFI of HLA‐DR on monocytes (R2 = 0.145, p < 0.001), B% was positively correlated with CD10−NEUT% (R2 = 0.291, p < 0.001), and MFI of HLA‐DR on monocytes was negatively correlated with CD10−NEUT% (R2 = 0.457, p < 0.001). Multivariate logistic regression analysis revealed that age, serous effusion, fatty liver, recurrent pancreatitis, and B% were independent risk factors for the occurrence of PPDM‐A.
Conclusion
Our study has first confirmed the correlation between PPDM‐A and lymphocyte subsets and CD10−NEUT%. Furthermore we indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM‐A. The mechanism of granulocyte and monocyte surface markers and B lymphocytes on PPDM‐A is worthy of study. This would help clarify the pathogenesis of PPDM‐A at the cellular level and potentially provide new strategies for immunotherapy and even disease prevention. [Correction added on 24 January 2025, after first online publication: the third subtitle in section has been changed to ‘Results’.]
In this study, we aimed to determine the value of lymphocyte subsets and granulocyte/monocyte markers in predicting the risk of post‐acute pancreatitis diabetes mellitus (PPDM‐A). Our study is the first to confirm the correlation between PPDM‐A and lymphocyte subsets and indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM‐A. The interaction mechanism of granulocyte and monocyte surface markers and B lymphocytes on glucose metabolism disorder after AP is worthy of further study.</description><identifier>ISSN: 1753-0393</identifier><identifier>ISSN: 1753-0407</identifier><identifier>EISSN: 1753-0407</identifier><identifier>DOI: 10.1111/1753-0407.70047</identifier><identifier>PMID: 39801164</identifier><language>eng</language><publisher>Melbourne: Wiley Publishing Asia Pty Ltd</publisher><subject>Acute Disease ; Adult ; Aged ; B-Lymphocytes - immunology ; Biomarkers - blood ; CD10 ; Diabetes ; Diabetes Mellitus - blood ; Female ; Flow Cytometry ; Granulocytes ; HLA‐DR ; Humans ; Lymphocytes ; Male ; MFI ; Middle Aged ; Monocytes ; Original ; Pancreatitis ; Pancreatitis - blood ; Pancreatitis - complications ; Pancreatitis - immunology ; PPDM‐A ; PPNG‐A ; Prognosis ; Regression analysis ; Risk Factors</subject><ispartof>Journal of diabetes, 2025-01, Vol.17 (1), p.e70047-n/a</ispartof><rights>2025 The Author(s). published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.</rights><rights>2025 The Author(s). Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.</rights><rights>2025. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3037-65236c0f8c5aa06d37a657bd03ff56f40309a9b58522060de19ef74affc4c8503</cites><orcidid>0000-0002-0017-2158</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725652/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725652/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39801164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Xiaoyan</creatorcontrib><creatorcontrib>Li, Xiaoling</creatorcontrib><creatorcontrib>Wang, Junsheng</creatorcontrib><creatorcontrib>Liu, Huiheng</creatorcontrib><title>B Lymphocyte—A Prognostic Indicator in Post‐Acute Pancreatitis Diabetes Mellitus</title><title>Journal of diabetes</title><addtitle>J Diabetes</addtitle><description>ABSTRACT
Objective
To determine the value of lymphocyte subsets and granulocyte/monocyte surface markers in predicting the risk of post‐acute pancreatitis diabetes (PPDM‐A).
Methods
This study included 308 in patients with acute pancreatitis (AP). The markers of granulocytes and monocytes and lymphocyte subsets were detected by flow cytometry, and the fluorescence intensity, absolute count and percentage were obtained. Based on the occurrence of diabetes after AP, patients were divided into two groups: PPDM‐A and PPNG‐A (post‐acute pancreatitis with normal glucose). Correlations between granulocyte and monocyte surface markers and lymphocyte subsets were analyzed. Binary logistic regression was used to analyze the potential influencing factors of PPDM‐A.
Results
Compared with patients with PPNG‐A, patients with PPDM‐A tend to be younger (p < 0.001) and have a higher proportion of fatty liver, recurrent pancreatitis, and hyperlipidemic pancreatitis. The results of linear regression showed that B% was negatively correlated with MFI of HLA‐DR on monocytes (R2 = 0.145, p < 0.001), B% was positively correlated with CD10−NEUT% (R2 = 0.291, p < 0.001), and MFI of HLA‐DR on monocytes was negatively correlated with CD10−NEUT% (R2 = 0.457, p < 0.001). Multivariate logistic regression analysis revealed that age, serous effusion, fatty liver, recurrent pancreatitis, and B% were independent risk factors for the occurrence of PPDM‐A.
Conclusion
Our study has first confirmed the correlation between PPDM‐A and lymphocyte subsets and CD10−NEUT%. Furthermore we indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM‐A. The mechanism of granulocyte and monocyte surface markers and B lymphocytes on PPDM‐A is worthy of study. This would help clarify the pathogenesis of PPDM‐A at the cellular level and potentially provide new strategies for immunotherapy and even disease prevention. [Correction added on 24 January 2025, after first online publication: the third subtitle in section has been changed to ‘Results’.]
In this study, we aimed to determine the value of lymphocyte subsets and granulocyte/monocyte markers in predicting the risk of post‐acute pancreatitis diabetes mellitus (PPDM‐A). Our study is the first to confirm the correlation between PPDM‐A and lymphocyte subsets and indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM‐A. The interaction mechanism of granulocyte and monocyte surface markers and B lymphocytes on glucose metabolism disorder after AP is worthy of further study.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>B-Lymphocytes - immunology</subject><subject>Biomarkers - blood</subject><subject>CD10</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - blood</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Granulocytes</subject><subject>HLA‐DR</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>MFI</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Original</subject><subject>Pancreatitis</subject><subject>Pancreatitis - blood</subject><subject>Pancreatitis - complications</subject><subject>Pancreatitis - immunology</subject><subject>PPDM‐A</subject><subject>PPNG‐A</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><issn>1753-0393</issn><issn>1753-0407</issn><issn>1753-0407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqFkb1u2zAUhYmgRX6czN0KAV2y2L4URVKaCuevdeEiHpKZoCnSZiCLDkkl8JZHyJAnzJNEqh2jzVIuJO79eO49OAh9wTDA7RliTkkfMuADDpDxPXS4q3x6f5OCHKCjEO4AGGeM7KMDUuSAMcsO0c1ZMlkvVwun1lG_Pr2Mkql389qFaFUyrkurZHQ-sXUybWuvT88j1USdTGWtvJbRRhuSCytnOuqQ_NZVZWMTjtFnI6ugT7Z3D91eXd6c_-xPrn-Mz0eTviJAeJ_RlDAFJldUSmAl4ZJRPiuBGEOZyYBAIYsZzWmaAoNS40IbnkljVKZyCqSHvm90V81sqUul6-hlJVbeLqVfCyet-LdT24WYuweBMU9pN76HTrcK3t03OkSxtEG1NmStXRMEwTTL84ICb9FvH9A71_i69ddSDFJMiqwTHG4o5V0IXpvdNhhEF5noQhFdQOJPZO2Pr3-b2PHvGbUA3QCPttLr_-mJXxdnG-E3dfuiAg</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Lin, Xiaoyan</creator><creator>Li, Xiaoling</creator><creator>Wang, Junsheng</creator><creator>Liu, Huiheng</creator><general>Wiley Publishing Asia Pty Ltd</general><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0017-2158</orcidid></search><sort><creationdate>202501</creationdate><title>B Lymphocyte—A Prognostic Indicator in Post‐Acute Pancreatitis Diabetes Mellitus</title><author>Lin, Xiaoyan ; Li, Xiaoling ; Wang, Junsheng ; Liu, Huiheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3037-65236c0f8c5aa06d37a657bd03ff56f40309a9b58522060de19ef74affc4c8503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>B-Lymphocytes - immunology</topic><topic>Biomarkers - blood</topic><topic>CD10</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - blood</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Granulocytes</topic><topic>HLA‐DR</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>MFI</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Original</topic><topic>Pancreatitis</topic><topic>Pancreatitis - blood</topic><topic>Pancreatitis - complications</topic><topic>Pancreatitis - immunology</topic><topic>PPDM‐A</topic><topic>PPNG‐A</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Xiaoyan</creatorcontrib><creatorcontrib>Li, Xiaoling</creatorcontrib><creatorcontrib>Wang, Junsheng</creatorcontrib><creatorcontrib>Liu, Huiheng</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Xiaoyan</au><au>Li, Xiaoling</au><au>Wang, Junsheng</au><au>Liu, Huiheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>B Lymphocyte—A Prognostic Indicator in Post‐Acute Pancreatitis Diabetes Mellitus</atitle><jtitle>Journal of diabetes</jtitle><addtitle>J Diabetes</addtitle><date>2025-01</date><risdate>2025</risdate><volume>17</volume><issue>1</issue><spage>e70047</spage><epage>n/a</epage><pages>e70047-n/a</pages><issn>1753-0393</issn><issn>1753-0407</issn><eissn>1753-0407</eissn><abstract>ABSTRACT
Objective
To determine the value of lymphocyte subsets and granulocyte/monocyte surface markers in predicting the risk of post‐acute pancreatitis diabetes (PPDM‐A).
Methods
This study included 308 in patients with acute pancreatitis (AP). The markers of granulocytes and monocytes and lymphocyte subsets were detected by flow cytometry, and the fluorescence intensity, absolute count and percentage were obtained. Based on the occurrence of diabetes after AP, patients were divided into two groups: PPDM‐A and PPNG‐A (post‐acute pancreatitis with normal glucose). Correlations between granulocyte and monocyte surface markers and lymphocyte subsets were analyzed. Binary logistic regression was used to analyze the potential influencing factors of PPDM‐A.
Results
Compared with patients with PPNG‐A, patients with PPDM‐A tend to be younger (p < 0.001) and have a higher proportion of fatty liver, recurrent pancreatitis, and hyperlipidemic pancreatitis. The results of linear regression showed that B% was negatively correlated with MFI of HLA‐DR on monocytes (R2 = 0.145, p < 0.001), B% was positively correlated with CD10−NEUT% (R2 = 0.291, p < 0.001), and MFI of HLA‐DR on monocytes was negatively correlated with CD10−NEUT% (R2 = 0.457, p < 0.001). Multivariate logistic regression analysis revealed that age, serous effusion, fatty liver, recurrent pancreatitis, and B% were independent risk factors for the occurrence of PPDM‐A.
Conclusion
Our study has first confirmed the correlation between PPDM‐A and lymphocyte subsets and CD10−NEUT%. Furthermore we indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM‐A. The mechanism of granulocyte and monocyte surface markers and B lymphocytes on PPDM‐A is worthy of study. This would help clarify the pathogenesis of PPDM‐A at the cellular level and potentially provide new strategies for immunotherapy and even disease prevention. [Correction added on 24 January 2025, after first online publication: the third subtitle in section has been changed to ‘Results’.]
In this study, we aimed to determine the value of lymphocyte subsets and granulocyte/monocyte markers in predicting the risk of post‐acute pancreatitis diabetes mellitus (PPDM‐A). Our study is the first to confirm the correlation between PPDM‐A and lymphocyte subsets and indicated that age, fatty liver, serous effusion, recurrent AP, and B% were independent risk factors for PPDM‐A. The interaction mechanism of granulocyte and monocyte surface markers and B lymphocytes on glucose metabolism disorder after AP is worthy of further study.</abstract><cop>Melbourne</cop><pub>Wiley Publishing Asia Pty Ltd</pub><pmid>39801164</pmid><doi>10.1111/1753-0407.70047</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0017-2158</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Adult Aged B-Lymphocytes - immunology Biomarkers - blood CD10 Diabetes Diabetes Mellitus - blood Female Flow Cytometry Granulocytes HLA‐DR Humans Lymphocytes Male MFI Middle Aged Monocytes Original Pancreatitis Pancreatitis - blood Pancreatitis - complications Pancreatitis - immunology PPDM‐A PPNG‐A Prognosis Regression analysis Risk Factors |
| title | B Lymphocyte—A Prognostic Indicator in Post‐Acute Pancreatitis Diabetes Mellitus |
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