Extensive homologous recombination safeguards oocyte genome integrity in mammals

Meiosis in mammalian oocytes is interrupted by a prolonged arrest at the germinal vesicle stage, during which oocytes have to repair DNA lesions to ensure genome integrity or otherwise undergo apoptosis. The FIRRM/FLIP-FIGNL1 complex dissociates RAD51 from the joint DNA molecules in both homologous...

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Veröffentlicht in:	Nucleic acids research 2025-01, Vol.53 (2)
Hauptverfasser:	Cao, Huiwen, Qiu, Cheng, Fang, Anxuan, Shang, Jianzhou, Xu, Wei, He, Lugeng, Duan, Xing, Zhang, Qianting, Yu, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA Damage DNA Repair Female Genome Integrity, Repair and Genomic Instability - genetics Homologous Recombination - genetics Meiosis - genetics Mice Mice, Knockout Oocytes - metabolism Rad51 Recombinase - genetics Rad51 Recombinase - metabolism
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