Efficacy and Satisfaction of a Chemically Characterized Malva sylvestris L. Extract-Based Food Supplement for Functional Constipation in Healthy Consumers: Preliminary Results of a Questionnaire-Based Survey
L. is rich in mucilage and is traditionally used for the management of numerous ailments including gastrointestinal disorders. Functional constipation (FC) is a gastrointestinal condition characterized by defecation anomalies such as infrequent stools, difficulty in stool passage, or both in the abs...
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description | L. is rich in mucilage and is traditionally used for the management of numerous ailments including gastrointestinal disorders. Functional constipation (FC) is a gastrointestinal condition characterized by defecation anomalies such as infrequent stools, difficulty in stool passage, or both in the absence of pathological abnormalities. FC can be reduced through lifestyle factors and dietary intervention. This consumer-based survey aimed to assess the efficacy of a
extract-based food supplement on the improvement of FC.
Healthy participants (
= 56), enrolled in a consumer-based survey, took a food supplement containing a chemically characterized
extract at a dose of 20 mL/day (containing 750 mg of
extract rich in food fiber and polyphenols) for 20 days on the advice of their pharmacist. The study evaluated bowel movement frequency (intestinal diary), stool consistency (Bristol Stool Form Scale, BSFS), and abdominal pain (Visual Analogue Scale, VAS), at baseline (T0), after 10 days (T1), and after 20 days (T2).
A significant increase in bowel movement frequency and stool consistency (
< 0.001) with a significant decrease in abdominal pain (
< 0.001) was observed. Additionally, this food supplement was well-tolerated as no adverse effects were reported by the enrolled subjects.
-based food supplement showed promising effectiveness and satisfaction in improving FC in healthy subjects, however, randomized clinical studies are needed to confirm these preliminary results. |
doi_str_mv | 10.3390/nu17010077 |
format | Article |
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extract-based food supplement on the improvement of FC.
Healthy participants (
= 56), enrolled in a consumer-based survey, took a food supplement containing a chemically characterized
extract at a dose of 20 mL/day (containing 750 mg of
extract rich in food fiber and polyphenols) for 20 days on the advice of their pharmacist. The study evaluated bowel movement frequency (intestinal diary), stool consistency (Bristol Stool Form Scale, BSFS), and abdominal pain (Visual Analogue Scale, VAS), at baseline (T0), after 10 days (T1), and after 20 days (T2).
A significant increase in bowel movement frequency and stool consistency (
< 0.001) with a significant decrease in abdominal pain (
< 0.001) was observed. Additionally, this food supplement was well-tolerated as no adverse effects were reported by the enrolled subjects.
-based food supplement showed promising effectiveness and satisfaction in improving FC in healthy subjects, however, randomized clinical studies are needed to confirm these preliminary results.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu17010077</identifier><identifier>PMID: 39796510</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abdominal Pain - drug therapy ; Adult ; Amino acids ; Constipation ; Constipation - drug therapy ; Consumer behavior ; Defecation - drug effects ; Dietary Fiber ; Dietary Supplements ; Female ; Food ; Glucose ; Healthy Volunteers ; Humans ; Laxatives ; Life sciences ; Male ; Malva ; Middle Aged ; Patient Satisfaction ; Plant Extracts - pharmacology ; Polyphenols ; Proteins ; Quality of life ; Questionnaires ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult</subject><ispartof>Nutrients, 2025-01, Vol.17 (1), p.77</ispartof><rights>COPYRIGHT 2025 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c327t-f0b718377f5887a13c532c1ed8d5e739e7f6d7f04130d3348440904211d114913</cites><orcidid>0000-0001-9437-676X ; 0000-0002-6199-0074 ; 0009-0000-0810-8460 ; 0000-0002-2877-9445 ; 0000-0001-8084-9976 ; 0000-0002-4870-7713 ; 0000-0002-6942-814X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723275/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723275/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39796510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lellis, Lorenza Francesca De</creatorcontrib><creatorcontrib>Ullah, Hammad</creatorcontrib><creatorcontrib>Morone, Maria Vittoria</creatorcontrib><creatorcontrib>Buccato, Daniele Giuseppe</creatorcontrib><creatorcontrib>Baldi, Alessandra</creatorcontrib><creatorcontrib>Minno, Alessandro Di</creatorcontrib><creatorcontrib>Larsen, Danaé S</creatorcontrib><creatorcontrib>Sacchi, Roberto</creatorcontrib><creatorcontrib>Daglia, Maria</creatorcontrib><title>Efficacy and Satisfaction of a Chemically Characterized Malva sylvestris L. Extract-Based Food Supplement for Functional Constipation in Healthy Consumers: Preliminary Results of a Questionnaire-Based Survey</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>L. is rich in mucilage and is traditionally used for the management of numerous ailments including gastrointestinal disorders. Functional constipation (FC) is a gastrointestinal condition characterized by defecation anomalies such as infrequent stools, difficulty in stool passage, or both in the absence of pathological abnormalities. FC can be reduced through lifestyle factors and dietary intervention. This consumer-based survey aimed to assess the efficacy of a
extract-based food supplement on the improvement of FC.
Healthy participants (
= 56), enrolled in a consumer-based survey, took a food supplement containing a chemically characterized
extract at a dose of 20 mL/day (containing 750 mg of
extract rich in food fiber and polyphenols) for 20 days on the advice of their pharmacist. The study evaluated bowel movement frequency (intestinal diary), stool consistency (Bristol Stool Form Scale, BSFS), and abdominal pain (Visual Analogue Scale, VAS), at baseline (T0), after 10 days (T1), and after 20 days (T2).
A significant increase in bowel movement frequency and stool consistency (
< 0.001) with a significant decrease in abdominal pain (
< 0.001) was observed. Additionally, this food supplement was well-tolerated as no adverse effects were reported by the enrolled subjects.
-based food supplement showed promising effectiveness and satisfaction in improving FC in healthy subjects, however, randomized clinical studies are needed to confirm these preliminary results.</description><subject>Abdominal Pain - drug therapy</subject><subject>Adult</subject><subject>Amino acids</subject><subject>Constipation</subject><subject>Constipation - drug therapy</subject><subject>Consumer behavior</subject><subject>Defecation - drug effects</subject><subject>Dietary Fiber</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Food</subject><subject>Glucose</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Laxatives</subject><subject>Life sciences</subject><subject>Male</subject><subject>Malva</subject><subject>Middle Aged</subject><subject>Patient Satisfaction</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>Proteins</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkttu1DAQhiMEolXpDQ-ALHGDkHaxYydOuEFltUuRFnEoXFtuMu66cuzUjleEl-SVcHaXHhDxRSzPN_8_Y0-WPSd4TmmN39hIOCYYc_4oO84xz2dlyejje_uj7DSEazx9HPOSPs2OaM3rsiD4OPu9VEo3shmRtC26kIMOSjaDdhY5hSRabKBLcWPGtJU-hcDrX9CiT9JsJQqj2UIYvA5oPUfLn8NEzN7LkIiVc0kx9r2BDuyAlPNoFe1OXBq0cDYMupc7L23ROUgzbMbdeezAh7foiwejO22lH9E3CNEMYV_V15hMU56V2sPB7iL6LYzPsidKmgCnh_9J9mO1_L44n60_f_i4OFvPGprzYabwJScV5VwVVcUloU1B84ZAW7UFcFoDV2XLFWaE4pZSVjGGa8xyQlpCWE3oSfZur9vHyw7aJjXopRG9112qVjipxcOI1Rtx5baCEJ6nEoqk8Oqg4N3N1I_odGjAGGnBxSAoKZIpI_lk9vIf9NpFny5xR1HOWE3xHXUlDQhtlZteYxIVZ1VOKc4LViVq_h8qrXZ6aGdB6XT-IOH1PqHxLgQP6rZJgsU0guJuBBP84v613KJ_B47-AQC_2A8</recordid><startdate>20250101</startdate><enddate>20250101</enddate><creator>Lellis, Lorenza Francesca De</creator><creator>Ullah, Hammad</creator><creator>Morone, Maria Vittoria</creator><creator>Buccato, Daniele Giuseppe</creator><creator>Baldi, Alessandra</creator><creator>Minno, Alessandro Di</creator><creator>Larsen, Danaé S</creator><creator>Sacchi, Roberto</creator><creator>Daglia, Maria</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9437-676X</orcidid><orcidid>https://orcid.org/0000-0002-6199-0074</orcidid><orcidid>https://orcid.org/0009-0000-0810-8460</orcidid><orcidid>https://orcid.org/0000-0002-2877-9445</orcidid><orcidid>https://orcid.org/0000-0001-8084-9976</orcidid><orcidid>https://orcid.org/0000-0002-4870-7713</orcidid><orcidid>https://orcid.org/0000-0002-6942-814X</orcidid></search><sort><creationdate>20250101</creationdate><title>Efficacy and Satisfaction of a Chemically Characterized Malva sylvestris L. 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Extract-Based Food Supplement for Functional Constipation in Healthy Consumers: Preliminary Results of a Questionnaire-Based Survey</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2025-01-01</date><risdate>2025</risdate><volume>17</volume><issue>1</issue><spage>77</spage><pages>77-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>L. is rich in mucilage and is traditionally used for the management of numerous ailments including gastrointestinal disorders. Functional constipation (FC) is a gastrointestinal condition characterized by defecation anomalies such as infrequent stools, difficulty in stool passage, or both in the absence of pathological abnormalities. FC can be reduced through lifestyle factors and dietary intervention. This consumer-based survey aimed to assess the efficacy of a
extract-based food supplement on the improvement of FC.
Healthy participants (
= 56), enrolled in a consumer-based survey, took a food supplement containing a chemically characterized
extract at a dose of 20 mL/day (containing 750 mg of
extract rich in food fiber and polyphenols) for 20 days on the advice of their pharmacist. The study evaluated bowel movement frequency (intestinal diary), stool consistency (Bristol Stool Form Scale, BSFS), and abdominal pain (Visual Analogue Scale, VAS), at baseline (T0), after 10 days (T1), and after 20 days (T2).
A significant increase in bowel movement frequency and stool consistency (
< 0.001) with a significant decrease in abdominal pain (
< 0.001) was observed. Additionally, this food supplement was well-tolerated as no adverse effects were reported by the enrolled subjects.
-based food supplement showed promising effectiveness and satisfaction in improving FC in healthy subjects, however, randomized clinical studies are needed to confirm these preliminary results.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39796510</pmid><doi>10.3390/nu17010077</doi><orcidid>https://orcid.org/0000-0001-9437-676X</orcidid><orcidid>https://orcid.org/0000-0002-6199-0074</orcidid><orcidid>https://orcid.org/0009-0000-0810-8460</orcidid><orcidid>https://orcid.org/0000-0002-2877-9445</orcidid><orcidid>https://orcid.org/0000-0001-8084-9976</orcidid><orcidid>https://orcid.org/0000-0002-4870-7713</orcidid><orcidid>https://orcid.org/0000-0002-6942-814X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Abdominal Pain - drug therapy Adult Amino acids Constipation Constipation - drug therapy Consumer behavior Defecation - drug effects Dietary Fiber Dietary Supplements Female Food Glucose Healthy Volunteers Humans Laxatives Life sciences Male Malva Middle Aged Patient Satisfaction Plant Extracts - pharmacology Polyphenols Proteins Quality of life Questionnaires Surveys and Questionnaires Treatment Outcome Young Adult |
title | Efficacy and Satisfaction of a Chemically Characterized Malva sylvestris L. Extract-Based Food Supplement for Functional Constipation in Healthy Consumers: Preliminary Results of a Questionnaire-Based Survey |
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