Irbesartan May Ameliorate Ventricular Remodeling by Inhibiting CREB-Mediated Cardiac Aldosterone Synthesis in Rats with Myocardial Infarction

Irbesartan improves ventricular remodeling (VR) following myocardial infarction (MI). This study investigates whether irbesartan attenuates VR by reducing aldosterone production in the heart and its underlying mechanisms. MI was induced in male Sprague-Dawley rats through coronary artery ligation. T...

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Veröffentlicht in:	International journal of molecular sciences 2024-12, Vol.26 (1), p.198
Hauptverfasser:	Li, Jie, Lu, Guihua, Deng, Haiwei, Gao, Xiuren, Zhai, Yuansheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Aldosterone - metabolism Angiotensin II Animals Blood pressure Cardiac function Cardiomyocytes Collagen Cyclic AMP Response Element-Binding Protein - metabolism Cytochrome P-450 CYP11B2 - genetics Cytochrome P-450 CYP11B2 - metabolism Endothelial Cells - drug effects Endothelial Cells - metabolism Heart attacks Irbesartan - pharmacology Irbesartan - therapeutic use Kinases Male Medical prognosis Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardium - metabolism Myocardium - pathology Phosphorylation Proteins Rats Rats, Sprague-Dawley Ventricular Remodeling - drug effects
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