SIR repression of a yeast heat shock gene: UAS and TATA footprints persist within heterochromatin

Previous work has suggested that products of the Saccharomyces cerevisiae S ilent I nformation R egulator ( SIR ) genes form a complex with histones, nucleated by cis ‐acting silencers or telomeres, which represses transcription in a position‐dependent but sequence‐independent fashion. While it is g...

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Veröffentlicht in:	The EMBO journal 1999-12, Vol.18 (24), p.7041-7055
Hauptverfasser:	Sekinger, E.A, Gross, D.S
Format:	Artikel
Sprache:	eng
Schlagworte:	alleles binding proteins Binding Sites DNA Footprinting DNA, Fungal - chemistry DNA, Fungal - genetics DNA-Binding Proteins Fungal Proteins - metabolism gene expression Gene Silencing genes Genes, Fungal - physiology Genes, Mating Type, Fungal genetic regulation Genotype heat shock factor heat shock proteins Heat-Shock Proteins - genetics heterochromatin Heterochromatin - genetics Heterochromatin - physiology histones Histones - metabolism HMRE gene HSP82 gene HSP90 Heat-Shock Proteins mating-type silencers Promoter Regions, Genetic regulator genes regulatory sequences Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins silencers Silent Information Regulator silent information regulators SIR gene TATA Box TATA-binding protein Telomere - genetics Telomere - physiology Trans-Activators - metabolism transcription (genetics) transcription factors transcriptional activators transcriptional silencing Yeasts Zinc Fingers
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