Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells

Activation of antigen‐presenting cells (APCs) by invariant constituents of pathogens such as lipopolysaccharide (LPS) or bacterial DNA (CpG‐DNA) initiates immune responses. We have analyzed the mitogen‐activated protein kinase (MAPK) pathways triggered by CpG‐DNA and their significance for cytokine...

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Veröffentlicht in:	The EMBO journal 1999-12, Vol.18 (24), p.6973-6982
Hauptverfasser:	Häcker, Hans, Mischak, Harald, Häcker, Georg, Eser, Sema, Prenzel, Norbert, Ullrich, Axel, Wagner, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - drug effects Antigen-Presenting Cells - immunology Antigen-Presenting Cells - physiology Bone Marrow Cells - cytology Bone Marrow Cells - immunology Cell Line Cells, Cultured CpG-DNA Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - physiology Deoxyribonucleic acid Dinucleoside Phosphates DNA ERK kinase ERK protein Gene Expression Regulation - immunology IL-12 innate immunity Interleukin-12 - biosynthesis Interleukin-12 - genetics lipopolysaccharides Lipopolysaccharides - pharmacology Luciferases - genetics Macrophages - drug effects Macrophages - immunology Macrophages - physiology MAP kinase MEK protein Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Oligodeoxyribonucleotides - pharmacology Recombinant Proteins - biosynthesis Thionucleotides TNF Transfection Tumor Necrosis Factor-alpha - genetics
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