NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p

Post‐translational acetylation of histone H4 N‐terminal tail in chromatin has been associated with several nuclear processes including transcription. We report the purification and characterization of a native multisubunit complex (NuA4) from yeast that acetylates nucleosomal histone H4. NuA4 has an...

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Veröffentlicht in:	The EMBO journal 1999-09, Vol.18 (18), p.5108-5119
Hauptverfasser:	Allard, Stéphane, Utley, Rhea T., Savard, Julie, Clarke, Astrid, Grant, Patrick, Brandl, Christopher J., Pillus, Lorraine, Workman, Jerry L., Côté, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation acetyltransferase Acetyltransferases - chemistry Acetyltransferases - genetics Acetyltransferases - metabolism Amino Acid Sequence ATM protein c-Myc protein Cell Cycle E2F protein ESA1 ESA1 gene Esa1 protein Genes, Fungal HeLa Cells Histone Acetyltransferases histone H4 histone H4 acetyltransferase Histones - chemistry Histones - metabolism Humans In Vitro Techniques Molecular Sequence Data Mutation NuA4 protein nucleosome Nucleosomes - metabolism Protein Structure, Quaternary Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Temperature TRA-1 gene Tra-1 protein TRA1 gene Tra1 protein transcription Transcription, Genetic VP16 protein Yeasts
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