Functional overlap between two classes of matrix-degrading proteases in wound healing

Retarded wound healing was found in mice deficient in the serine protease precursor plasminogen, as well as in wild‐type mice treated with the metalloprotease inhibitor galardin, but in both cases wound closure was ultimately completed in all mice within 60 days. The expression of several matrix met...

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Veröffentlicht in:	The EMBO journal 1999-09, Vol.18 (17), p.4645-4656
Hauptverfasser:	Lund, Leif R., Rømer, John, Bugge, Thomas H., Nielsen, Boye S., Frandsen, Thomas L., Degen, Jay L., Stephens, Ross W., Danø, Keld
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement - drug effects Dipeptides - pharmacology Gene Expression Regulation, Enzymologic Immunohistochemistry keratinocytes Keratinocytes - drug effects Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - metabolism metalloprotease Mice Mice, Inbred C57BL plasminogen Plasminogen - genetics Plasminogen - physiology Protease Inhibitors - pharmacology serine protease Skin - anatomy & histology Skin - enzymology Time Factors wound healing Wound Healing - drug effects Wound Healing - physiology
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