A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes

Human E‐cadherin promotes entry of the bacterial pathogen Listeria monocytogenes into mammalian cells by interacting with internalin (InlA), a bacterial surface protein. Here we show that mouse E‐cadherin, although very similar to human E‐cadherin (85% identity), is not a receptor for internalin. By...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The EMBO journal 1999-07, Vol.18 (14), p.3956-3963
Hauptverfasser:	Lecuit, Marc, Dramsi, Shaynoor, Gottardi, Cara, Fedor-Chaiken, Mary, Gumbiner, Barry, Cossart, Pascale
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Amino acids Animal models Animals Bacterial Proteins Bacterial Proteins - metabolism Bacteriology Cadherins Cadherins - chemistry Cadherins - metabolism Cell Line Disease Models, Animal E-cadherin Endocytosis Female Guinea Pigs Human health and pathology Humans Infectious diseases internalin invasion Life Sciences Listeria Listeria monocytogenes Listeria monocytogenes - growth & development Listeria monocytogenes - pathogenicity Listeriosis Listeriosis - microbiology Mice Mice, Inbred BALB C Microbiology and Parasitology Models, Molecular Molecular Sequence Data Pathogens Phylogeny Proline Proline - genetics Proline - metabolism Protein Binding Rats Recombinant Fusion Proteins Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Species Specificity specificity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!