Novel processing in a mammalian nuclear 28S pre-rRNA: tissue-specific elimination of an 'intron' bearing a hidden break site

Splitting and apparent splicing of ribosomal RNA, both previously unknown in vertebrates, were found in rodents of the genus Ctenomys . Instead of being formed by a single molecule of 4.4 kb, 28S rRNA is split in two molecules of 2.6 and 1.8 kb. A hidden break, mapping within a 106 bp ‘intron’ locat...

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Veröffentlicht in:	The EMBO journal 1999-06, Vol.18 (11), p.3107-3118
Hauptverfasser:	Melen, Gustavo J., Pesce, C.Gustavo, Rossi, María Susana, Kornblihtt, Alberto R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Blotting, Northern Cells, Cultured Ctenomys Electrophoresis, Polyacrylamide Gel Evolution, Molecular Introns - genetics Male mammalian cells Mice Models, Genetic Molecular Sequence Data Molecular Weight Nucleic Acid Conformation Organ Specificity Rats Repetitive Sequences, Nucleic Acid ribosomal RNA processing RNA Precursors - chemistry RNA Precursors - genetics RNA Precursors - metabolism RNA Splicing - genetics RNA, Ribosomal, 28S - chemistry RNA, Ribosomal, 28S - genetics RNA, Ribosomal, 28S - metabolism Rodentia - genetics Testis - cytology Testis - metabolism Thermodynamics
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