Urokinase receptor-dependent and -independent p56/59(hck) activation state is a molecular switch between myelomonocytic cell motility and adherence

Anchorage-independent myelomonocytic cells acquire adherence within minutes of differentiation stimuli, such as the proteolytically inactive N-terminal fragment of urokinase binding to its cognate glycosylphosphatidylinositol (GPI)-anchored receptor. Here, we report that urokinase-treated differenti...

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Veröffentlicht in:	The EMBO journal 1999-06, Vol.18 (11), p.3013-3023
Hauptverfasser:	Chiaradonna, F, Fontana, L, Iavarone, C, Carriero, M V, Scholz, G, Barone, M V, Stoppelli, M P
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Calcitriol - pharmacology Cell Adhesion - drug effects Cell Differentiation Cell Movement - drug effects Cytoskeleton - drug effects Enzyme Activation Humans Macrophages - cytology Macrophages - drug effects Macrophages - enzymology Macrophages - metabolism Mice Monocytes - cytology Monocytes - drug effects Monocytes - enzymology Monocytes - metabolism Mutation Phenotype Phosphorylation - drug effects Protein Kinase Inhibitors Protein Kinases - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-hck Receptors, Cell Surface - metabolism Receptors, Urokinase Plasminogen Activator Temperature Transfection Transforming Growth Factor beta - pharmacology Tumor Cells, Cultured Urokinase-Type Plasminogen Activator - metabolism Urokinase-Type Plasminogen Activator - pharmacology
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