Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer
Cardiovascular diseases are associated with higher cancer risk. However, their relationship with metastatic cancer, the primary determinant of cancer prognosis, has not been studied. This study aimed to determine the association between atherosclerotic cardiovascular disease and the presence of meta...
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| Veröffentlicht in: | JACC CardioOncology 2024-12, Vol.6 (6), p.949-961 |
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| creator | Caller, Tal Fardman, Alexander Gerber, Yariv Moshkovits, Yonatan Tiosano, Shmuel Kaplan, Alon Kalstein, Maia Bayshtok, Gabriella Itkin, Tomer Avigdor, Abraham Naftali-Shani, Nili Leor, Jonathan Maor, Elad |
| description | Cardiovascular diseases are associated with higher cancer risk. However, their relationship with metastatic cancer, the primary determinant of cancer prognosis, has not been studied.
This study aimed to determine the association between atherosclerotic cardiovascular disease and the presence of metastasis at the time of cancer diagnosis.
We analyzed data from 21,654 self-referred adults who were free of cancer and atherosclerotic cardiovascular disease at enrollment in a preventive health care program. To exclude silent cancers, a 1-year blanking period was implemented at the start of the follow-up. The relationship between atherosclerotic cardiovascular disease and metastatic cancer was assessed using cause-specific Cox regression, treating incident atherosclerotic cardiovascular disease as a time-dependent covariate. Interaction analysis further elucidated differences in metastasis risks between middle-aged adults (Q1-Q3 age ≤54 years) and older adults (Q4 age >54 years).
Over a median follow-up of 6 years (Q1-Q3: 3-12 years), we recorded 1,333 cases of atherosclerotic cardiovascular disease (6.2%) and 1,793 cases of cancer (8.3%), of which 1,036 (4.8 %) were nonmetastatic and 757 (3.5%) were metastatic at diagnosis. After adjusting for shared risk factors, atherosclerotic cardiovascular disease was independently associated with an increased risk of cancer metastasis at the time of cancer diagnosis (HR: 1.75; 95% CI: 1.33-2.29). This association was more pronounced among middle-aged adults (HR: 1.64; 95% CI: 1.03-2.61; P = 0.036) than in older adults (HR: 1.11; 95% CI: 0.78-1.60; P = 0.56), with a significant interaction (Pinteraction = 0.039).
Atherosclerotic cardiovascular disease is associated with a significantly increased risk of cancer, specifically metastasis at the time of cancer diagnosis, particularly in middle-aged adults. Recognizing this association could enhance the prevention and treatment of metastatic cancer in patients with atherosclerotic cardiovascular disease.
[Display omitted] |
| doi_str_mv | 10.1016/j.jaccao.2024.07.020 |
| format | Article |
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This study aimed to determine the association between atherosclerotic cardiovascular disease and the presence of metastasis at the time of cancer diagnosis.
We analyzed data from 21,654 self-referred adults who were free of cancer and atherosclerotic cardiovascular disease at enrollment in a preventive health care program. To exclude silent cancers, a 1-year blanking period was implemented at the start of the follow-up. The relationship between atherosclerotic cardiovascular disease and metastatic cancer was assessed using cause-specific Cox regression, treating incident atherosclerotic cardiovascular disease as a time-dependent covariate. Interaction analysis further elucidated differences in metastasis risks between middle-aged adults (Q1-Q3 age ≤54 years) and older adults (Q4 age >54 years).
Over a median follow-up of 6 years (Q1-Q3: 3-12 years), we recorded 1,333 cases of atherosclerotic cardiovascular disease (6.2%) and 1,793 cases of cancer (8.3%), of which 1,036 (4.8 %) were nonmetastatic and 757 (3.5%) were metastatic at diagnosis. After adjusting for shared risk factors, atherosclerotic cardiovascular disease was independently associated with an increased risk of cancer metastasis at the time of cancer diagnosis (HR: 1.75; 95% CI: 1.33-2.29). This association was more pronounced among middle-aged adults (HR: 1.64; 95% CI: 1.03-2.61; P = 0.036) than in older adults (HR: 1.11; 95% CI: 0.78-1.60; P = 0.56), with a significant interaction (Pinteraction = 0.039).
Atherosclerotic cardiovascular disease is associated with a significantly increased risk of cancer, specifically metastasis at the time of cancer diagnosis, particularly in middle-aged adults. Recognizing this association could enhance the prevention and treatment of metastatic cancer in patients with atherosclerotic cardiovascular disease.
[Display omitted]</description><identifier>ISSN: 2666-0873</identifier><identifier>EISSN: 2666-0873</identifier><identifier>DOI: 10.1016/j.jaccao.2024.07.020</identifier><identifier>PMID: 39801640</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>atherosclerosis ; cancer ; cardiovascular diseases ; ischemic heart disease ; metastasis ; myocardial infarction ; Original Research ; reverse cardio-oncology ; stroke</subject><ispartof>JACC CardioOncology, 2024-12, Vol.6 (6), p.949-961</ispartof><rights>2024 The Authors</rights><rights>2024 The Authors.</rights><rights>2024 The Authors 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2580-23876a6eea000506d31b2017c24e1be790e4775ea965403b274e98c2159484713</cites><orcidid>0000-0002-5087-0464 ; 0009-0001-7890-9789 ; 0000-0002-1748-4297</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711827/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711827/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39801640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caller, Tal</creatorcontrib><creatorcontrib>Fardman, Alexander</creatorcontrib><creatorcontrib>Gerber, Yariv</creatorcontrib><creatorcontrib>Moshkovits, Yonatan</creatorcontrib><creatorcontrib>Tiosano, Shmuel</creatorcontrib><creatorcontrib>Kaplan, Alon</creatorcontrib><creatorcontrib>Kalstein, Maia</creatorcontrib><creatorcontrib>Bayshtok, Gabriella</creatorcontrib><creatorcontrib>Itkin, Tomer</creatorcontrib><creatorcontrib>Avigdor, Abraham</creatorcontrib><creatorcontrib>Naftali-Shani, Nili</creatorcontrib><creatorcontrib>Leor, Jonathan</creatorcontrib><creatorcontrib>Maor, Elad</creatorcontrib><title>Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer</title><title>JACC CardioOncology</title><addtitle>JACC CardioOncol</addtitle><description>Cardiovascular diseases are associated with higher cancer risk. However, their relationship with metastatic cancer, the primary determinant of cancer prognosis, has not been studied.
This study aimed to determine the association between atherosclerotic cardiovascular disease and the presence of metastasis at the time of cancer diagnosis.
We analyzed data from 21,654 self-referred adults who were free of cancer and atherosclerotic cardiovascular disease at enrollment in a preventive health care program. To exclude silent cancers, a 1-year blanking period was implemented at the start of the follow-up. The relationship between atherosclerotic cardiovascular disease and metastatic cancer was assessed using cause-specific Cox regression, treating incident atherosclerotic cardiovascular disease as a time-dependent covariate. Interaction analysis further elucidated differences in metastasis risks between middle-aged adults (Q1-Q3 age ≤54 years) and older adults (Q4 age >54 years).
Over a median follow-up of 6 years (Q1-Q3: 3-12 years), we recorded 1,333 cases of atherosclerotic cardiovascular disease (6.2%) and 1,793 cases of cancer (8.3%), of which 1,036 (4.8 %) were nonmetastatic and 757 (3.5%) were metastatic at diagnosis. After adjusting for shared risk factors, atherosclerotic cardiovascular disease was independently associated with an increased risk of cancer metastasis at the time of cancer diagnosis (HR: 1.75; 95% CI: 1.33-2.29). This association was more pronounced among middle-aged adults (HR: 1.64; 95% CI: 1.03-2.61; P = 0.036) than in older adults (HR: 1.11; 95% CI: 0.78-1.60; P = 0.56), with a significant interaction (Pinteraction = 0.039).
Atherosclerotic cardiovascular disease is associated with a significantly increased risk of cancer, specifically metastasis at the time of cancer diagnosis, particularly in middle-aged adults. Recognizing this association could enhance the prevention and treatment of metastatic cancer in patients with atherosclerotic cardiovascular disease.
[Display omitted]</description><subject>atherosclerosis</subject><subject>cancer</subject><subject>cardiovascular diseases</subject><subject>ischemic heart disease</subject><subject>metastasis</subject><subject>myocardial infarction</subject><subject>Original Research</subject><subject>reverse cardio-oncology</subject><subject>stroke</subject><issn>2666-0873</issn><issn>2666-0873</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9UcFOGzEUtBBVQSl_UKE9csny7PXa3gsoCi0g0fbSqkfrxfsgjjZrsJ1I_H0dhQK99GJbzzPzRjOMfeZQc-DqfFWv0DkMtQAha9A1CDhgx0IpNQWjm8N37yN2ktIKAETLuZLmIztqOlNUJByz5SwvKYbkhnJm76o5xt6HLSa3GTBWVz4RJkrVLFI1Syk4j5n66rfPy-p2dL6nMVffKGPKuOPj2Fffw7h-m8xxdBQ_sQ_3OCQ6ebkn7NfXLz_nN9O7H9e389nd1InWwFQ0RitURFgMt6D6hi8EcO2EJL4g3QFJrVvCTrUSmoXQkjrjBG87aaTmzYRd7nUfN4s19a7YizjYx-jXGJ9tQG___Rn90j6EreVcc26ELgpnLwoxPG0oZbv2ydEw4Ehhk2zDW2mMUUIWqNxDXYkwRbp_3cPB7oqyK7svyu6KsqBtKarQTt97fCX9raUALvYAKkltPUWbnKcSY-8juWz74P-_4Q82zqZo</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Caller, Tal</creator><creator>Fardman, Alexander</creator><creator>Gerber, Yariv</creator><creator>Moshkovits, Yonatan</creator><creator>Tiosano, Shmuel</creator><creator>Kaplan, Alon</creator><creator>Kalstein, Maia</creator><creator>Bayshtok, Gabriella</creator><creator>Itkin, Tomer</creator><creator>Avigdor, Abraham</creator><creator>Naftali-Shani, Nili</creator><creator>Leor, Jonathan</creator><creator>Maor, Elad</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5087-0464</orcidid><orcidid>https://orcid.org/0009-0001-7890-9789</orcidid><orcidid>https://orcid.org/0000-0002-1748-4297</orcidid></search><sort><creationdate>202412</creationdate><title>Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer</title><author>Caller, Tal ; Fardman, Alexander ; Gerber, Yariv ; Moshkovits, Yonatan ; Tiosano, Shmuel ; Kaplan, Alon ; Kalstein, Maia ; Bayshtok, Gabriella ; Itkin, Tomer ; Avigdor, Abraham ; Naftali-Shani, Nili ; Leor, Jonathan ; Maor, Elad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2580-23876a6eea000506d31b2017c24e1be790e4775ea965403b274e98c2159484713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>atherosclerosis</topic><topic>cancer</topic><topic>cardiovascular diseases</topic><topic>ischemic heart disease</topic><topic>metastasis</topic><topic>myocardial infarction</topic><topic>Original Research</topic><topic>reverse cardio-oncology</topic><topic>stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caller, Tal</creatorcontrib><creatorcontrib>Fardman, Alexander</creatorcontrib><creatorcontrib>Gerber, Yariv</creatorcontrib><creatorcontrib>Moshkovits, Yonatan</creatorcontrib><creatorcontrib>Tiosano, Shmuel</creatorcontrib><creatorcontrib>Kaplan, Alon</creatorcontrib><creatorcontrib>Kalstein, Maia</creatorcontrib><creatorcontrib>Bayshtok, Gabriella</creatorcontrib><creatorcontrib>Itkin, Tomer</creatorcontrib><creatorcontrib>Avigdor, Abraham</creatorcontrib><creatorcontrib>Naftali-Shani, Nili</creatorcontrib><creatorcontrib>Leor, Jonathan</creatorcontrib><creatorcontrib>Maor, Elad</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JACC CardioOncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caller, Tal</au><au>Fardman, Alexander</au><au>Gerber, Yariv</au><au>Moshkovits, Yonatan</au><au>Tiosano, Shmuel</au><au>Kaplan, Alon</au><au>Kalstein, Maia</au><au>Bayshtok, Gabriella</au><au>Itkin, Tomer</au><au>Avigdor, Abraham</au><au>Naftali-Shani, Nili</au><au>Leor, Jonathan</au><au>Maor, Elad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer</atitle><jtitle>JACC CardioOncology</jtitle><addtitle>JACC CardioOncol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>6</volume><issue>6</issue><spage>949</spage><epage>961</epage><pages>949-961</pages><issn>2666-0873</issn><eissn>2666-0873</eissn><abstract>Cardiovascular diseases are associated with higher cancer risk. However, their relationship with metastatic cancer, the primary determinant of cancer prognosis, has not been studied.
This study aimed to determine the association between atherosclerotic cardiovascular disease and the presence of metastasis at the time of cancer diagnosis.
We analyzed data from 21,654 self-referred adults who were free of cancer and atherosclerotic cardiovascular disease at enrollment in a preventive health care program. To exclude silent cancers, a 1-year blanking period was implemented at the start of the follow-up. The relationship between atherosclerotic cardiovascular disease and metastatic cancer was assessed using cause-specific Cox regression, treating incident atherosclerotic cardiovascular disease as a time-dependent covariate. Interaction analysis further elucidated differences in metastasis risks between middle-aged adults (Q1-Q3 age ≤54 years) and older adults (Q4 age >54 years).
Over a median follow-up of 6 years (Q1-Q3: 3-12 years), we recorded 1,333 cases of atherosclerotic cardiovascular disease (6.2%) and 1,793 cases of cancer (8.3%), of which 1,036 (4.8 %) were nonmetastatic and 757 (3.5%) were metastatic at diagnosis. After adjusting for shared risk factors, atherosclerotic cardiovascular disease was independently associated with an increased risk of cancer metastasis at the time of cancer diagnosis (HR: 1.75; 95% CI: 1.33-2.29). This association was more pronounced among middle-aged adults (HR: 1.64; 95% CI: 1.03-2.61; P = 0.036) than in older adults (HR: 1.11; 95% CI: 0.78-1.60; P = 0.56), with a significant interaction (Pinteraction = 0.039).
Atherosclerotic cardiovascular disease is associated with a significantly increased risk of cancer, specifically metastasis at the time of cancer diagnosis, particularly in middle-aged adults. Recognizing this association could enhance the prevention and treatment of metastatic cancer in patients with atherosclerotic cardiovascular disease.
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| fulltext | fulltext |
| identifier | ISSN: 2666-0873 |
| ispartof | JACC CardioOncology, 2024-12, Vol.6 (6), p.949-961 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | atherosclerosis cancer cardiovascular diseases ischemic heart disease metastasis myocardial infarction Original Research reverse cardio-oncology stroke |
| title | Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer |
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