Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study
Gastrointestinal (GI) involvement is highly prevalent in systemic sclerosis (SSc) and significantly affects patient quality of life and clinical outcomes. This study investigates the potential of undernutrition scores, namely the Control of Nutritional Status (CONUT) score and the Prognostic Nutriti...
Gespeichert in:
| Veröffentlicht in: | Rheumatology international 2025-01, Vol.45 (1), p.21, Article 21 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 21 |
| container_title | Rheumatology international |
| container_volume | 45 |
| creator | Öz, Nuran Gezer, Halise Hande Karabulut, Yusuf Duruöz, Mehmet Tuncay |
| description | Gastrointestinal (GI) involvement is highly prevalent in systemic sclerosis (SSc) and significantly affects patient quality of life and clinical outcomes. This study investigates the potential of undernutrition scores, namely the Control of Nutritional Status (CONUT) score and the Prognostic Nutrition Index (PNI), in predicting GI involvement in patients with SSc. A total of 82 patients diagnosed with SSc were enrolled in this cross-sectional study. Participants were evaluated using the UCLA Scleroderma Clinical Research Consortium Gastrointestinal Tract 2.0 (UCLA GIT 2.0) tool, which assesses the severity of GI symptoms and their impact on health-related quality of life. Malnutrition was assessed using CONUT and PNI scores derived from routine laboratory parameters. The correlation between these malnutrition indices and the UCLA GIT 2.0 scores was analyzed to determine the predictive value of malnutrition in GI involvement. The study found that patients with higher CONUT scores, indicating malnutrition, had significantly higher total UCLA GIT 2.0 scores. A moderate positive correlation was observed between CONUT scores and total UCLA GIT 2.0 scores (
r
=.539;
p
|
| doi_str_mv | 10.1007/s00296-024-05783-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11711249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153878781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c312t-62af0b241cab23e2bea13df41c23e09b18a0caf8d43d34e640692f75a296d41b3</originalsourceid><addsrcrecordid>eNp9kU1P3DAQhq2qVflo_wAHZKmXXkI9thMnXCqEoEVC4kKl3izHcRajJF48TtH-e7y7dAscKh88o3nmtWdeQo6AnQBj6hsyxpuqYFwWrFS1KPg7sg9SqAIq9vv9i3iPHCDeMwaqqthHsicapVQpy33yeIYYrDfJh4mGnk5zin6dmIFiMmlG6qfOW4f00ac7ujCYYvBTcpj8BlqNyxTGNZZjTG70lqIdXAzo8ZQaanOEBTq7k5271SfyoTcDus_P9yH5dXlxe_6zuL75cXV-dl1YATwVFTc9a7kEa1ouHG-dAdH1Oc8Za1qoDbOmrzspOiFdJVnV8F6VJi-mk9CKQ_J9q7uc29F11k0pmkEvox9NXOlgvH5dmfydXoQ_GkABcNlkha_PCjE8zHlsPXq0bhjM5MKMWkApapUPZPTLG_Q-zDHPvKG4qksJLFN8S20WE12_-w0wvTZWb43V2Vi9MVbz3HT8co5dy18nMyC2AObStHDx39v_kX0CSLiytg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3152785410</pqid></control><display><type>article</type><title>Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Öz, Nuran ; Gezer, Halise Hande ; Karabulut, Yusuf ; Duruöz, Mehmet Tuncay</creator><creatorcontrib>Öz, Nuran ; Gezer, Halise Hande ; Karabulut, Yusuf ; Duruöz, Mehmet Tuncay</creatorcontrib><description>Gastrointestinal (GI) involvement is highly prevalent in systemic sclerosis (SSc) and significantly affects patient quality of life and clinical outcomes. This study investigates the potential of undernutrition scores, namely the Control of Nutritional Status (CONUT) score and the Prognostic Nutrition Index (PNI), in predicting GI involvement in patients with SSc. A total of 82 patients diagnosed with SSc were enrolled in this cross-sectional study. Participants were evaluated using the UCLA Scleroderma Clinical Research Consortium Gastrointestinal Tract 2.0 (UCLA GIT 2.0) tool, which assesses the severity of GI symptoms and their impact on health-related quality of life. Malnutrition was assessed using CONUT and PNI scores derived from routine laboratory parameters. The correlation between these malnutrition indices and the UCLA GIT 2.0 scores was analyzed to determine the predictive value of malnutrition in GI involvement. The study found that patients with higher CONUT scores, indicating malnutrition, had significantly higher total UCLA GIT 2.0 scores. A moderate positive correlation was observed between CONUT scores and total UCLA GIT 2.0 scores (
r
=.539;
p
<.01), while a negative correlation was found between CONUT scores and PNI (
r
= −.513;
p
<.01). These findings suggest that malnutrition, as measured by CONUT and PNI, is associated with greater GI involvement in SSc. This study shows that malnutrition indices such as CONUT and PNI in SSc patients, together with the UCLA GIT 2.0 score, may serve as usefull predictors of GI involvment in routine clinical practice.
Key-points
(1) We investigated the relationship between the UCLA GIT 2.0 score, which assesses GI involvement in patients with systemic sclerosis (SSc), and the CONUT score and PNI, indicators of malnutrition.
(2) In the study, a negative correlation was detected between UCLA GIT 2.0 scores and CONUT score and a positive correlation was found with PNI.
(3) CONUT and PNI scores derived from routine laboratory parameters provide a simple and effective method to assess malnutrition and predict GI complications in SSc patients.</description><identifier>ISSN: 1437-160X</identifier><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-024-05783-2</identifier><identifier>PMID: 39777545</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Cross-Sectional Studies ; Female ; Gastrointestinal Diseases - diagnosis ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - physiopathology ; Humans ; Male ; Malnutrition ; Malnutrition - diagnosis ; Malnutrition - etiology ; Malnutrition - physiopathology ; Medicine ; Medicine & Public Health ; Middle Aged ; Nutrition Assessment ; Nutritional Status ; Observational Research ; Quality of Life ; Rheumatology ; Scleroderma ; Scleroderma, Systemic - complications ; Scleroderma, Systemic - physiopathology ; Severity of Illness Index</subject><ispartof>Rheumatology international, 2025-01, Vol.45 (1), p.21, Article 21</ispartof><rights>The Author(s) 2025</rights><rights>2025. The Author(s).</rights><rights>Copyright Springer Nature B.V. Jan 2025</rights><rights>The Author(s) 2025 2025</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c312t-62af0b241cab23e2bea13df41c23e09b18a0caf8d43d34e640692f75a296d41b3</cites><orcidid>0000-0002-1002-962X ; 0000-0001-8790-304X ; 0000-0003-2690-6196 ; 0000-0003-3584-2788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-024-05783-2$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-024-05783-2$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39777545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Öz, Nuran</creatorcontrib><creatorcontrib>Gezer, Halise Hande</creatorcontrib><creatorcontrib>Karabulut, Yusuf</creatorcontrib><creatorcontrib>Duruöz, Mehmet Tuncay</creatorcontrib><title>Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>Gastrointestinal (GI) involvement is highly prevalent in systemic sclerosis (SSc) and significantly affects patient quality of life and clinical outcomes. This study investigates the potential of undernutrition scores, namely the Control of Nutritional Status (CONUT) score and the Prognostic Nutrition Index (PNI), in predicting GI involvement in patients with SSc. A total of 82 patients diagnosed with SSc were enrolled in this cross-sectional study. Participants were evaluated using the UCLA Scleroderma Clinical Research Consortium Gastrointestinal Tract 2.0 (UCLA GIT 2.0) tool, which assesses the severity of GI symptoms and their impact on health-related quality of life. Malnutrition was assessed using CONUT and PNI scores derived from routine laboratory parameters. The correlation between these malnutrition indices and the UCLA GIT 2.0 scores was analyzed to determine the predictive value of malnutrition in GI involvement. The study found that patients with higher CONUT scores, indicating malnutrition, had significantly higher total UCLA GIT 2.0 scores. A moderate positive correlation was observed between CONUT scores and total UCLA GIT 2.0 scores (
r
=.539;
p
<.01), while a negative correlation was found between CONUT scores and PNI (
r
= −.513;
p
<.01). These findings suggest that malnutrition, as measured by CONUT and PNI, is associated with greater GI involvement in SSc. This study shows that malnutrition indices such as CONUT and PNI in SSc patients, together with the UCLA GIT 2.0 score, may serve as usefull predictors of GI involvment in routine clinical practice.
Key-points
(1) We investigated the relationship between the UCLA GIT 2.0 score, which assesses GI involvement in patients with systemic sclerosis (SSc), and the CONUT score and PNI, indicators of malnutrition.
(2) In the study, a negative correlation was detected between UCLA GIT 2.0 scores and CONUT score and a positive correlation was found with PNI.
(3) CONUT and PNI scores derived from routine laboratory parameters provide a simple and effective method to assess malnutrition and predict GI complications in SSc patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gastrointestinal Diseases - diagnosis</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Diseases - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Malnutrition</subject><subject>Malnutrition - diagnosis</subject><subject>Malnutrition - etiology</subject><subject>Malnutrition - physiopathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nutrition Assessment</subject><subject>Nutritional Status</subject><subject>Observational Research</subject><subject>Quality of Life</subject><subject>Rheumatology</subject><subject>Scleroderma</subject><subject>Scleroderma, Systemic - complications</subject><subject>Scleroderma, Systemic - physiopathology</subject><subject>Severity of Illness Index</subject><issn>1437-160X</issn><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1P3DAQhq2qVflo_wAHZKmXXkI9thMnXCqEoEVC4kKl3izHcRajJF48TtH-e7y7dAscKh88o3nmtWdeQo6AnQBj6hsyxpuqYFwWrFS1KPg7sg9SqAIq9vv9i3iPHCDeMwaqqthHsicapVQpy33yeIYYrDfJh4mGnk5zin6dmIFiMmlG6qfOW4f00ac7ujCYYvBTcpj8BlqNyxTGNZZjTG70lqIdXAzo8ZQaanOEBTq7k5271SfyoTcDus_P9yH5dXlxe_6zuL75cXV-dl1YATwVFTc9a7kEa1ouHG-dAdH1Oc8Za1qoDbOmrzspOiFdJVnV8F6VJi-mk9CKQ_J9q7uc29F11k0pmkEvox9NXOlgvH5dmfydXoQ_GkABcNlkha_PCjE8zHlsPXq0bhjM5MKMWkApapUPZPTLG_Q-zDHPvKG4qksJLFN8S20WE12_-w0wvTZWb43V2Vi9MVbz3HT8co5dy18nMyC2AObStHDx39v_kX0CSLiytg</recordid><startdate>20250108</startdate><enddate>20250108</enddate><creator>Öz, Nuran</creator><creator>Gezer, Halise Hande</creator><creator>Karabulut, Yusuf</creator><creator>Duruöz, Mehmet Tuncay</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1002-962X</orcidid><orcidid>https://orcid.org/0000-0001-8790-304X</orcidid><orcidid>https://orcid.org/0000-0003-2690-6196</orcidid><orcidid>https://orcid.org/0000-0003-3584-2788</orcidid></search><sort><creationdate>20250108</creationdate><title>Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study</title><author>Öz, Nuran ; Gezer, Halise Hande ; Karabulut, Yusuf ; Duruöz, Mehmet Tuncay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-62af0b241cab23e2bea13df41c23e09b18a0caf8d43d34e640692f75a296d41b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gastrointestinal Diseases - diagnosis</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Diseases - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Malnutrition</topic><topic>Malnutrition - diagnosis</topic><topic>Malnutrition - etiology</topic><topic>Malnutrition - physiopathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nutrition Assessment</topic><topic>Nutritional Status</topic><topic>Observational Research</topic><topic>Quality of Life</topic><topic>Rheumatology</topic><topic>Scleroderma</topic><topic>Scleroderma, Systemic - complications</topic><topic>Scleroderma, Systemic - physiopathology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Öz, Nuran</creatorcontrib><creatorcontrib>Gezer, Halise Hande</creatorcontrib><creatorcontrib>Karabulut, Yusuf</creatorcontrib><creatorcontrib>Duruöz, Mehmet Tuncay</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Öz, Nuran</au><au>Gezer, Halise Hande</au><au>Karabulut, Yusuf</au><au>Duruöz, Mehmet Tuncay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2025-01-08</date><risdate>2025</risdate><volume>45</volume><issue>1</issue><spage>21</spage><pages>21-</pages><artnum>21</artnum><issn>1437-160X</issn><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>Gastrointestinal (GI) involvement is highly prevalent in systemic sclerosis (SSc) and significantly affects patient quality of life and clinical outcomes. This study investigates the potential of undernutrition scores, namely the Control of Nutritional Status (CONUT) score and the Prognostic Nutrition Index (PNI), in predicting GI involvement in patients with SSc. A total of 82 patients diagnosed with SSc were enrolled in this cross-sectional study. Participants were evaluated using the UCLA Scleroderma Clinical Research Consortium Gastrointestinal Tract 2.0 (UCLA GIT 2.0) tool, which assesses the severity of GI symptoms and their impact on health-related quality of life. Malnutrition was assessed using CONUT and PNI scores derived from routine laboratory parameters. The correlation between these malnutrition indices and the UCLA GIT 2.0 scores was analyzed to determine the predictive value of malnutrition in GI involvement. The study found that patients with higher CONUT scores, indicating malnutrition, had significantly higher total UCLA GIT 2.0 scores. A moderate positive correlation was observed between CONUT scores and total UCLA GIT 2.0 scores (
r
=.539;
p
<.01), while a negative correlation was found between CONUT scores and PNI (
r
= −.513;
p
<.01). These findings suggest that malnutrition, as measured by CONUT and PNI, is associated with greater GI involvement in SSc. This study shows that malnutrition indices such as CONUT and PNI in SSc patients, together with the UCLA GIT 2.0 score, may serve as usefull predictors of GI involvment in routine clinical practice.
Key-points
(1) We investigated the relationship between the UCLA GIT 2.0 score, which assesses GI involvement in patients with systemic sclerosis (SSc), and the CONUT score and PNI, indicators of malnutrition.
(2) In the study, a negative correlation was detected between UCLA GIT 2.0 scores and CONUT score and a positive correlation was found with PNI.
(3) CONUT and PNI scores derived from routine laboratory parameters provide a simple and effective method to assess malnutrition and predict GI complications in SSc patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39777545</pmid><doi>10.1007/s00296-024-05783-2</doi><orcidid>https://orcid.org/0000-0002-1002-962X</orcidid><orcidid>https://orcid.org/0000-0001-8790-304X</orcidid><orcidid>https://orcid.org/0000-0003-2690-6196</orcidid><orcidid>https://orcid.org/0000-0003-3584-2788</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1437-160X |
| ispartof | Rheumatology international, 2025-01, Vol.45 (1), p.21, Article 21 |
| issn | 1437-160X 0172-8172 1437-160X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11711249 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Cross-Sectional Studies Female Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - etiology Gastrointestinal Diseases - physiopathology Humans Male Malnutrition Malnutrition - diagnosis Malnutrition - etiology Malnutrition - physiopathology Medicine Medicine & Public Health Middle Aged Nutrition Assessment Nutritional Status Observational Research Quality of Life Rheumatology Scleroderma Scleroderma, Systemic - complications Scleroderma, Systemic - physiopathology Severity of Illness Index |
| title | Association of nutritional status indices with gastrointestinal symptoms in systemic sclerosis: a cross-sectional study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T03%3A07%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20nutritional%20status%20indices%20with%20gastrointestinal%20symptoms%20in%20systemic%20sclerosis:%20a%20cross-sectional%20study&rft.jtitle=Rheumatology%20international&rft.au=%C3%96z,%20Nuran&rft.date=2025-01-08&rft.volume=45&rft.issue=1&rft.spage=21&rft.pages=21-&rft.artnum=21&rft.issn=1437-160X&rft.eissn=1437-160X&rft_id=info:doi/10.1007/s00296-024-05783-2&rft_dat=%3Cproquest_pubme%3E3153878781%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3152785410&rft_id=info:pmid/39777545&rfr_iscdi=true |