Role of Targeted Sequencing in Routine Diagnostics of Spitz Melanocytic Neoplasms—An Analysis of 70 Cases

ABSTRACT Background There is growing evidence that the Spitz group of melanocytic neoplasms should be restricted to those harboring kinase receptor fusions and HRAS mutations/11p15 amplification. The presence of genomic alterations characteristic of conventional melanomas (BRAF and NRAS mutations) p...

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Veröffentlicht in:	Journal of cutaneous pathology 2025-02, Vol.52 (2), p.141-153
Hauptverfasser:	Šekoranja, Daja, Zupan, Andrej, Matjašič, Alenka, Boštjančič, Emanuela, Calonje, Eduardo, Pižem, Jože
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged atypical Spitz tumor Child Child, Preschool Diagnosis, Differential Female Genomics GTP Phosphohydrolases - genetics High-Throughput Nucleotide Sequencing - methods Humans Male malignant Spitz tumor MAP Kinase Kinase 1 - genetics MAP2K1 Melanoma Melanoma - diagnosis Melanoma - genetics Membrane Proteins - genetics Middle Aged Mutation Nevus, Epithelioid and Spindle Cell - diagnosis Nevus, Epithelioid and Spindle Cell - genetics Nevus, Epithelioid and Spindle Cell - pathology Original Physical characteristics Proto-Oncogene Proteins B-raf - genetics Skin Neoplasms - diagnosis Skin Neoplasms - genetics Skin Neoplasms - pathology Spitz nevus spitzoid Tumors Young Adult
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