Brazilian older adults with Alzheimer’s Disease Exhibit Telomere Shortening

Brazilian older adults with Alzheimer’s Disease Exhibit Telomere Shortening

Background The Brazilian population has been experiencing an increase in the number of older adults, with a simultaneous rise in the incidence of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). Telomeres are structures located at the ends of chromosomes that maintain the structural int...

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Veröffentlicht in:Alzheimer's & dementia 2024-12, Vol.20 (S1), p.n/a
Hauptverfasser: Graciano, Guilherme Fonseca, Soares, Thayana Oliveira, Cintra, Marco Túlio, Malheiro, Olívio Brito, Júnior, Luciano Pimenta, Milagre, Samuel Oliveira, Ribeiro, Letícia Jabur, Kimoto, Leonardo Ryuiti, de Souza, Aline Siqueira, Fonseca, João Henrique, Lima, Nuno de Andrade Rezende, Rocha, Camila Dias, Viana, Bernardo M, Jansen, Ann Kristine, dos Santos, Rodrigo Ribeiro, Bicalho, Maria Aparecida Camargos
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Basic Science and Pathogenesis
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container_issue S1
container_start_page
container_title Alzheimer's & dementia
container_volume 20
creator Graciano, Guilherme Fonseca
Soares, Thayana Oliveira
Cintra, Marco Túlio
Malheiro, Olívio Brito
Júnior, Luciano Pimenta
Milagre, Samuel Oliveira
Ribeiro, Letícia Jabur
Kimoto, Leonardo Ryuiti
de Souza, Aline Siqueira
Fonseca, João Henrique
Lima, Nuno de Andrade Rezende
Rocha, Camila Dias
Viana, Bernardo M
Jansen, Ann Kristine
dos Santos, Rodrigo Ribeiro
Bicalho, Maria Aparecida Camargos
description Background The Brazilian population has been experiencing an increase in the number of older adults, with a simultaneous rise in the incidence of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). Telomeres are structures located at the ends of chromosomes that maintain the structural integrity of the chromosome. There is a shortage of studies correlating telomeres and cognition. This study aimed to assess the relationship between telomere length and different cognitive profiles. Method A cross‐sectional study was conducted at the Outpatient Reference Center for Older Adults at the University Hospital of the Universidade Federal de Minas Gerais (UFMG), Brazil. The sample consisted of older adults without cognitive impairment (control group), those with MCI, and those with AD`s dementia (ADD). Participants underwent geriatric and neuropsychological evaluation for clinical and cognitive assessment. DNA analysis from peripheral blood samples was performed using a saline method. Telomere relative length was analyzed using RT‐PCR. Multivariate linear regression analysis was conducted to examine the association between telomere relative length and the sample. Result The sample comprised 90 participants, with 30 individuals in each group (control, MCI, and AD). The majority of the sample comprised women (68.9%), with an average education of 4.56 ± 3.70 years. The percentage of women was higher in all groups. The ADD group had a higher average age compared to the others, with a mean age of 79.5 (75.0‐83.5), p = 0.0060. Education was lower in the MCI group compared to the control group (25, p = 0.001). A shorter telomere length was observed in the ADD group (225.51), followed by the control group (428.27) and the MCI group (448.05) (p
doi_str_mv 10.1002/alz.092662
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Telomeres are structures located at the ends of chromosomes that maintain the structural integrity of the chromosome. There is a shortage of studies correlating telomeres and cognition. This study aimed to assess the relationship between telomere length and different cognitive profiles. Method A cross‐sectional study was conducted at the Outpatient Reference Center for Older Adults at the University Hospital of the Universidade Federal de Minas Gerais (UFMG), Brazil. The sample consisted of older adults without cognitive impairment (control group), those with MCI, and those with AD`s dementia (ADD). Participants underwent geriatric and neuropsychological evaluation for clinical and cognitive assessment. DNA analysis from peripheral blood samples was performed using a saline method. Telomere relative length was analyzed using RT‐PCR. Multivariate linear regression analysis was conducted to examine the association between telomere relative length and the sample. Result The sample comprised 90 participants, with 30 individuals in each group (control, MCI, and AD). The majority of the sample comprised women (68.9%), with an average education of 4.56 ± 3.70 years. The percentage of women was higher in all groups. The ADD group had a higher average age compared to the others, with a mean age of 79.5 (75.0‐83.5), p = 0.0060. Education was lower in the MCI group compared to the control group (25, p = 0.001). A shorter telomere length was observed in the ADD group (225.51), followed by the control group (428.27) and the MCI group (448.05) (p &lt;0.001). The variable dyslipidemia was significantly associated with telomere length (p = 0.034). Other variables did not differ significantly. Conclusion It was observed that the relative telomere length was associated with the ADD, with a smaller telomere relative length in this group compared to the others, and an association with dyslipidemia.</description><identifier>ISSN: 1552-5260</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.092662</identifier><language>eng</language><publisher>Hoboken: John Wiley and Sons Inc</publisher><subject>Basic Science and Pathogenesis</subject><ispartof>Alzheimer's &amp; dementia, 2024-12, Vol.20 (S1), p.n/a</ispartof><rights>2024 The Alzheimer's Association. published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710189/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710189/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,1412,11543,27905,27906,45555,45556,46033,46457,53772,53774</link.rule.ids></links><search><creatorcontrib>Graciano, Guilherme Fonseca</creatorcontrib><creatorcontrib>Soares, Thayana Oliveira</creatorcontrib><creatorcontrib>Cintra, Marco Túlio</creatorcontrib><creatorcontrib>Malheiro, Olívio Brito</creatorcontrib><creatorcontrib>Júnior, Luciano Pimenta</creatorcontrib><creatorcontrib>Milagre, Samuel Oliveira</creatorcontrib><creatorcontrib>Ribeiro, Letícia Jabur</creatorcontrib><creatorcontrib>Kimoto, Leonardo Ryuiti</creatorcontrib><creatorcontrib>de Souza, Aline Siqueira</creatorcontrib><creatorcontrib>Fonseca, João Henrique</creatorcontrib><creatorcontrib>Lima, Nuno de Andrade Rezende</creatorcontrib><creatorcontrib>Rocha, Camila Dias</creatorcontrib><creatorcontrib>Viana, Bernardo M</creatorcontrib><creatorcontrib>Jansen, Ann Kristine</creatorcontrib><creatorcontrib>dos Santos, Rodrigo Ribeiro</creatorcontrib><creatorcontrib>Bicalho, Maria Aparecida Camargos</creatorcontrib><title>Brazilian older adults with Alzheimer’s Disease Exhibit Telomere Shortening</title><title>Alzheimer's &amp; dementia</title><description>Background The Brazilian population has been experiencing an increase in the number of older adults, with a simultaneous rise in the incidence of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). Telomeres are structures located at the ends of chromosomes that maintain the structural integrity of the chromosome. There is a shortage of studies correlating telomeres and cognition. This study aimed to assess the relationship between telomere length and different cognitive profiles. Method A cross‐sectional study was conducted at the Outpatient Reference Center for Older Adults at the University Hospital of the Universidade Federal de Minas Gerais (UFMG), Brazil. The sample consisted of older adults without cognitive impairment (control group), those with MCI, and those with AD`s dementia (ADD). Participants underwent geriatric and neuropsychological evaluation for clinical and cognitive assessment. DNA analysis from peripheral blood samples was performed using a saline method. Telomere relative length was analyzed using RT‐PCR. Multivariate linear regression analysis was conducted to examine the association between telomere relative length and the sample. Result The sample comprised 90 participants, with 30 individuals in each group (control, MCI, and AD). The majority of the sample comprised women (68.9%), with an average education of 4.56 ± 3.70 years. The percentage of women was higher in all groups. The ADD group had a higher average age compared to the others, with a mean age of 79.5 (75.0‐83.5), p = 0.0060. Education was lower in the MCI group compared to the control group (25, p = 0.001). A shorter telomere length was observed in the ADD group (225.51), followed by the control group (428.27) and the MCI group (448.05) (p &lt;0.001). The variable dyslipidemia was significantly associated with telomere length (p = 0.034). Other variables did not differ significantly. Conclusion It was observed that the relative telomere length was associated with the ADD, with a smaller telomere relative length in this group compared to the others, and an association with dyslipidemia.</description><subject>Basic Science and Pathogenesis</subject><issn>1552-5260</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><recordid>eNp9kL1OwzAUhS0EEqWw8ASekVpsp7HjCZVSfqQiBsrCYrnOdWPkJpWdUtqJ1-D1eBKCUlViYbpXOt_5hoPQOSV9Sgi71H7bJ5Jxzg5Qh6Yp66VMyMP9z8kxOonxjZAByWjaQY_XQW-dd7rElc8hYJ2vfB3x2tUFHvptAW4B4fvzK-IbF0FHwOOPws1cjafgqyYD_FxUoYbSlfNTdGS1j3C2u130cjueju57k6e7h9Fw0jOUS9YDYYAkA2rzLCHAmMiNNSTj1tKcSZCcCyqMlpAmws6SVBuhUzAil5yBzbKki65a73I1W0BuoKyD9moZ3EKHjaq0U3-T0hVqXr0rSgUlNJON4aI1mFDFGMDuy5So3ylVM6Vqp2xg2sJr52HzD6mGk9dd5wcr43m6</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Graciano, Guilherme Fonseca</creator><creator>Soares, Thayana Oliveira</creator><creator>Cintra, Marco Túlio</creator><creator>Malheiro, Olívio Brito</creator><creator>Júnior, Luciano Pimenta</creator><creator>Milagre, Samuel Oliveira</creator><creator>Ribeiro, Letícia Jabur</creator><creator>Kimoto, Leonardo Ryuiti</creator><creator>de Souza, Aline Siqueira</creator><creator>Fonseca, João Henrique</creator><creator>Lima, Nuno de Andrade Rezende</creator><creator>Rocha, Camila Dias</creator><creator>Viana, Bernardo M</creator><creator>Jansen, Ann Kristine</creator><creator>dos Santos, Rodrigo Ribeiro</creator><creator>Bicalho, Maria Aparecida Camargos</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>202412</creationdate><title>Brazilian older adults with Alzheimer’s Disease Exhibit Telomere Shortening</title><author>Graciano, Guilherme Fonseca ; Soares, Thayana Oliveira ; Cintra, Marco Túlio ; Malheiro, Olívio Brito ; Júnior, Luciano Pimenta ; Milagre, Samuel Oliveira ; Ribeiro, Letícia Jabur ; Kimoto, Leonardo Ryuiti ; de Souza, Aline Siqueira ; Fonseca, João Henrique ; Lima, Nuno de Andrade Rezende ; Rocha, Camila Dias ; Viana, Bernardo M ; Jansen, Ann Kristine ; dos Santos, Rodrigo Ribeiro ; Bicalho, Maria Aparecida Camargos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1692-e7ce0341fd830e227dcfc086ff1d29e966717ca9e537fb35ac7a5ec7d962ef883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Basic Science and Pathogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Graciano, Guilherme Fonseca</creatorcontrib><creatorcontrib>Soares, Thayana Oliveira</creatorcontrib><creatorcontrib>Cintra, Marco Túlio</creatorcontrib><creatorcontrib>Malheiro, Olívio Brito</creatorcontrib><creatorcontrib>Júnior, Luciano Pimenta</creatorcontrib><creatorcontrib>Milagre, Samuel Oliveira</creatorcontrib><creatorcontrib>Ribeiro, Letícia Jabur</creatorcontrib><creatorcontrib>Kimoto, Leonardo Ryuiti</creatorcontrib><creatorcontrib>de Souza, Aline Siqueira</creatorcontrib><creatorcontrib>Fonseca, João Henrique</creatorcontrib><creatorcontrib>Lima, Nuno de Andrade Rezende</creatorcontrib><creatorcontrib>Rocha, Camila Dias</creatorcontrib><creatorcontrib>Viana, Bernardo M</creatorcontrib><creatorcontrib>Jansen, Ann Kristine</creatorcontrib><creatorcontrib>dos Santos, Rodrigo Ribeiro</creatorcontrib><creatorcontrib>Bicalho, Maria Aparecida Camargos</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alzheimer's &amp; dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Graciano, Guilherme Fonseca</au><au>Soares, Thayana Oliveira</au><au>Cintra, Marco Túlio</au><au>Malheiro, Olívio Brito</au><au>Júnior, Luciano Pimenta</au><au>Milagre, Samuel Oliveira</au><au>Ribeiro, Letícia Jabur</au><au>Kimoto, Leonardo Ryuiti</au><au>de Souza, Aline Siqueira</au><au>Fonseca, João Henrique</au><au>Lima, Nuno de Andrade Rezende</au><au>Rocha, Camila Dias</au><au>Viana, Bernardo M</au><au>Jansen, Ann Kristine</au><au>dos Santos, Rodrigo Ribeiro</au><au>Bicalho, Maria Aparecida Camargos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brazilian older adults with Alzheimer’s Disease Exhibit Telomere Shortening</atitle><jtitle>Alzheimer's &amp; dementia</jtitle><date>2024-12</date><risdate>2024</risdate><volume>20</volume><issue>S1</issue><epage>n/a</epage><issn>1552-5260</issn><eissn>1552-5279</eissn><abstract>Background The Brazilian population has been experiencing an increase in the number of older adults, with a simultaneous rise in the incidence of Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD). Telomeres are structures located at the ends of chromosomes that maintain the structural integrity of the chromosome. There is a shortage of studies correlating telomeres and cognition. This study aimed to assess the relationship between telomere length and different cognitive profiles. Method A cross‐sectional study was conducted at the Outpatient Reference Center for Older Adults at the University Hospital of the Universidade Federal de Minas Gerais (UFMG), Brazil. The sample consisted of older adults without cognitive impairment (control group), those with MCI, and those with AD`s dementia (ADD). Participants underwent geriatric and neuropsychological evaluation for clinical and cognitive assessment. DNA analysis from peripheral blood samples was performed using a saline method. Telomere relative length was analyzed using RT‐PCR. Multivariate linear regression analysis was conducted to examine the association between telomere relative length and the sample. Result The sample comprised 90 participants, with 30 individuals in each group (control, MCI, and AD). The majority of the sample comprised women (68.9%), with an average education of 4.56 ± 3.70 years. The percentage of women was higher in all groups. The ADD group had a higher average age compared to the others, with a mean age of 79.5 (75.0‐83.5), p = 0.0060. Education was lower in the MCI group compared to the control group (25, p = 0.001). A shorter telomere length was observed in the ADD group (225.51), followed by the control group (428.27) and the MCI group (448.05) (p &lt;0.001). The variable dyslipidemia was significantly associated with telomere length (p = 0.034). Other variables did not differ significantly. Conclusion It was observed that the relative telomere length was associated with the ADD, with a smaller telomere relative length in this group compared to the others, and an association with dyslipidemia.</abstract><cop>Hoboken</cop><pub>John Wiley and Sons Inc</pub><doi>10.1002/alz.092662</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record>
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title Brazilian older adults with Alzheimer’s Disease Exhibit Telomere Shortening
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