Generating a novel and reliable human iPSC‐derived midbrain organoid model of sporadic progressive supranuclear palsy

Background The accumulation of abnormal tau protein in neurons and glia in the human brain is the defining feature of neurodegenerative diseases known as tauopathies. Progressive supranuclear palsy (PSP), the most common primary tauopathy, is typified by selective vulnerability of dopaminergic neuro...

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Veröffentlicht in:	Alzheimer's & dementia 2024-12, Vol.20 (S1), p.n/a
Hauptverfasser:	Selecky, Grace A., Whitney, Kristen R., Krassner, Margaret M., Cervera, Alessandra, De Sanctis, Claudia, Almazan, Victoria Flores, Delica, Sean Thomas, Kim, SoongHo, Farrell, Kurt W., Christie, Thomas D., Iida, Megan A, Sarrafha, Lily, Parfitt, Gustavo, Walker, Ruth H., Nirenberg, Melissa J, Riboldi, Giulietta M., Frucht, Steven J., Ahfeldt, Tim, Temple, Sally, Crary, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Science and Pathogenesis
Online-Zugang:	Volltext
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