Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis
Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests...
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| Veröffentlicht in: | Journal of biomaterials applications 2025-01, Vol.39 (6), p.592-606 |
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| creator | Bayir, Yasin Erkayman, Beyzagül Albayrak, Abdulmecit Palabiyik-Yücelik, Şaziye Sezin Can, Sümeyra Hanci, Hayrunisa Tunç, Fatih Halici, Hamza Civelek, Maide Sena Sevim, Melike Yurdgülü, Emir Enis Metin, Önder |
| description | Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns. In L929 mouse fibroblast cell line, BA, ZB and graphene hydrogels did not show any toxic effects, either alone or doped Graphene Hydrogel forms, except at very high doses. These substances showed antioxidant properties by protecting cells against H2O2 damage. The migration test performed on boron products also confirms the protective effect of boron products. In this study, the synthesis of graphene hydrogels was made for the first time, and their characterization was completed with appropriate instrumental analyses. The results of the biocompatibility tests of graphene hydrogels show that they are at least 96% biocompatible. |
| doi_str_mv | 10.1177/08853282241268673 |
| format | Article |
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For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns. In L929 mouse fibroblast cell line, BA, ZB and graphene hydrogels did not show any toxic effects, either alone or doped Graphene Hydrogel forms, except at very high doses. These substances showed antioxidant properties by protecting cells against H2O2 damage. The migration test performed on boron products also confirms the protective effect of boron products. In this study, the synthesis of graphene hydrogels was made for the first time, and their characterization was completed with appropriate instrumental analyses. The results of the biocompatibility tests of graphene hydrogels show that they are at least 96% biocompatible.</description><identifier>ISSN: 0885-3282</identifier><identifier>ISSN: 1530-8022</identifier><identifier>EISSN: 1530-8022</identifier><identifier>DOI: 10.1177/08853282241268673</identifier><identifier>PMID: 39302915</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biomaterials Processing ; Borates - chemistry ; Borates - pharmacology ; Boric Acids - chemistry ; Boric Acids - pharmacology ; Burns - drug therapy ; Cell Line ; Cell Survival - drug effects ; Fibroblasts - drug effects ; Graphite - chemistry ; Graphite - pharmacology ; Hydrogels - chemistry ; Hydrogels - pharmacology ; Hydrogen Peroxide - chemistry ; Materials Testing ; Mice ; Wound Healing - drug effects ; Zinc - chemistry ; Zinc - pharmacology ; Zinc Compounds</subject><ispartof>Journal of biomaterials applications, 2025-01, Vol.39 (6), p.592-606</ispartof><rights>The Author(s) 2024</rights><rights>The Author(s) 2024 2024 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c278t-d73aecb7577e68460db06f33532700fd428619b3a5b3b47aeb4a50e0f321f90d3</cites><orcidid>0000-0003-3562-6727 ; 0000-0002-9636-1753</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/08853282241268673$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/08853282241268673$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39302915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bayir, Yasin</creatorcontrib><creatorcontrib>Erkayman, Beyzagül</creatorcontrib><creatorcontrib>Albayrak, Abdulmecit</creatorcontrib><creatorcontrib>Palabiyik-Yücelik, Şaziye Sezin</creatorcontrib><creatorcontrib>Can, Sümeyra</creatorcontrib><creatorcontrib>Hanci, Hayrunisa</creatorcontrib><creatorcontrib>Tunç, Fatih</creatorcontrib><creatorcontrib>Halici, Hamza</creatorcontrib><creatorcontrib>Civelek, Maide Sena</creatorcontrib><creatorcontrib>Sevim, Melike</creatorcontrib><creatorcontrib>Yurdgülü, Emir Enis</creatorcontrib><creatorcontrib>Metin, Önder</creatorcontrib><title>Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis</title><title>Journal of biomaterials applications</title><addtitle>J Biomater Appl</addtitle><description>Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns. In L929 mouse fibroblast cell line, BA, ZB and graphene hydrogels did not show any toxic effects, either alone or doped Graphene Hydrogel forms, except at very high doses. These substances showed antioxidant properties by protecting cells against H2O2 damage. The migration test performed on boron products also confirms the protective effect of boron products. In this study, the synthesis of graphene hydrogels was made for the first time, and their characterization was completed with appropriate instrumental analyses. The results of the biocompatibility tests of graphene hydrogels show that they are at least 96% biocompatible.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biomaterials Processing</subject><subject>Borates - chemistry</subject><subject>Borates - pharmacology</subject><subject>Boric Acids - chemistry</subject><subject>Boric Acids - pharmacology</subject><subject>Burns - drug therapy</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Fibroblasts - drug effects</subject><subject>Graphite - chemistry</subject><subject>Graphite - pharmacology</subject><subject>Hydrogels - chemistry</subject><subject>Hydrogels - pharmacology</subject><subject>Hydrogen Peroxide - chemistry</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>Wound Healing - drug effects</subject><subject>Zinc - chemistry</subject><subject>Zinc - pharmacology</subject><subject>Zinc Compounds</subject><issn>0885-3282</issn><issn>1530-8022</issn><issn>1530-8022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRAVXQo_gAvykUvK2I7jhAuCio9KlXqBc-SPSdZVEgfbW2n5I_xdvGypQJV6saV5b97Mm0fIKwbnjCn1FtpWCt5yXjPetI0ST8iGSQFVC5w_JZsDXh0Ip-R5SjcAILu6eUZORSeAd0xuyK-PIXpLtfWO6sXRn36x1ISoM1IXVnR0jHrd4oJ0u3cxjDgl6jD5cSnYECI1u7jQHFHnGZf8jl4u9NbnGMqrjZ983lfGBxvmVWd_LNCMKac_82ZvYyj4FEZv9VRqetonn16Qk0FPCV_e_Wfk--dP3y6-VlfXXy4vPlxVlqs2V04JjdYoqRQ2bd2AM9AMQpSzKIDB1bxtWGeElkaYWmk0tZaAMAjOhg6cOCPvj7rrzszobLEQ9dSv0c867vugff8_svhtP4bbvgQAqmtkUXhzpxDDj10x1s8-WZwmvWDYpV4wUBJkA1Co7EgtnlOKONzPYXAQVP2DREvP638XvO_4G2EhnB8JSY_Y34QSRznYI4q_AdjrrV4</recordid><startdate>20250101</startdate><enddate>20250101</enddate><creator>Bayir, Yasin</creator><creator>Erkayman, Beyzagül</creator><creator>Albayrak, Abdulmecit</creator><creator>Palabiyik-Yücelik, Şaziye Sezin</creator><creator>Can, Sümeyra</creator><creator>Hanci, Hayrunisa</creator><creator>Tunç, Fatih</creator><creator>Halici, Hamza</creator><creator>Civelek, Maide Sena</creator><creator>Sevim, Melike</creator><creator>Yurdgülü, Emir Enis</creator><creator>Metin, Önder</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3562-6727</orcidid><orcidid>https://orcid.org/0000-0002-9636-1753</orcidid></search><sort><creationdate>20250101</creationdate><title>Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis</title><author>Bayir, Yasin ; Erkayman, Beyzagül ; Albayrak, Abdulmecit ; Palabiyik-Yücelik, Şaziye Sezin ; Can, Sümeyra ; Hanci, Hayrunisa ; Tunç, Fatih ; Halici, Hamza ; Civelek, Maide Sena ; Sevim, Melike ; Yurdgülü, Emir Enis ; Metin, Önder</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-d73aecb7577e68460db06f33532700fd428619b3a5b3b47aeb4a50e0f321f90d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biomaterials Processing</topic><topic>Borates - chemistry</topic><topic>Borates - pharmacology</topic><topic>Boric Acids - chemistry</topic><topic>Boric Acids - pharmacology</topic><topic>Burns - drug therapy</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Fibroblasts - drug effects</topic><topic>Graphite - chemistry</topic><topic>Graphite - pharmacology</topic><topic>Hydrogels - chemistry</topic><topic>Hydrogels - pharmacology</topic><topic>Hydrogen Peroxide - chemistry</topic><topic>Materials Testing</topic><topic>Mice</topic><topic>Wound Healing - drug effects</topic><topic>Zinc - chemistry</topic><topic>Zinc - pharmacology</topic><topic>Zinc Compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bayir, Yasin</creatorcontrib><creatorcontrib>Erkayman, Beyzagül</creatorcontrib><creatorcontrib>Albayrak, Abdulmecit</creatorcontrib><creatorcontrib>Palabiyik-Yücelik, Şaziye Sezin</creatorcontrib><creatorcontrib>Can, Sümeyra</creatorcontrib><creatorcontrib>Hanci, Hayrunisa</creatorcontrib><creatorcontrib>Tunç, Fatih</creatorcontrib><creatorcontrib>Halici, Hamza</creatorcontrib><creatorcontrib>Civelek, Maide Sena</creatorcontrib><creatorcontrib>Sevim, Melike</creatorcontrib><creatorcontrib>Yurdgülü, Emir Enis</creatorcontrib><creatorcontrib>Metin, Önder</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomaterials applications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bayir, Yasin</au><au>Erkayman, Beyzagül</au><au>Albayrak, Abdulmecit</au><au>Palabiyik-Yücelik, Şaziye Sezin</au><au>Can, Sümeyra</au><au>Hanci, Hayrunisa</au><au>Tunç, Fatih</au><au>Halici, Hamza</au><au>Civelek, Maide Sena</au><au>Sevim, Melike</au><au>Yurdgülü, Emir Enis</au><au>Metin, Önder</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis</atitle><jtitle>Journal of biomaterials applications</jtitle><addtitle>J Biomater Appl</addtitle><date>2025-01-01</date><risdate>2025</risdate><volume>39</volume><issue>6</issue><spage>592</spage><epage>606</epage><pages>592-606</pages><issn>0885-3282</issn><issn>1530-8022</issn><eissn>1530-8022</eissn><abstract>Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns. In L929 mouse fibroblast cell line, BA, ZB and graphene hydrogels did not show any toxic effects, either alone or doped Graphene Hydrogel forms, except at very high doses. These substances showed antioxidant properties by protecting cells against H2O2 damage. The migration test performed on boron products also confirms the protective effect of boron products. In this study, the synthesis of graphene hydrogels was made for the first time, and their characterization was completed with appropriate instrumental analyses. The results of the biocompatibility tests of graphene hydrogels show that they are at least 96% biocompatible.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>39302915</pmid><doi>10.1177/08853282241268673</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-3562-6727</orcidid><orcidid>https://orcid.org/0000-0002-9636-1753</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 0885-3282 1530-8022 1530-8022 |
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| source | MEDLINE; SAGE Complete |
| subjects | Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antioxidants - chemistry Antioxidants - pharmacology Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomaterials Processing Borates - chemistry Borates - pharmacology Boric Acids - chemistry Boric Acids - pharmacology Burns - drug therapy Cell Line Cell Survival - drug effects Fibroblasts - drug effects Graphite - chemistry Graphite - pharmacology Hydrogels - chemistry Hydrogels - pharmacology Hydrogen Peroxide - chemistry Materials Testing Mice Wound Healing - drug effects Zinc - chemistry Zinc - pharmacology Zinc Compounds |
| title | Boric acid and zinc borate doped graphene hydrogels designed for burn treatment: In vitro viability-biocompatibility tests and microbiological analysis |
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