Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice
The orphan nuclear receptor RORβ is expressed in areas of the central nervous system which are involved in the processing of sensory information, including spinal cord, thalamus and sensory cerebellar cortices. Additionally, RORβ localizes to the three principal anatomical components of the mammalia...
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| Veröffentlicht in: | The EMBO journal 1998-07, Vol.17 (14), p.3867-3877 |
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| creator | André, Elisabeth Conquet, François Steinmayr, Markus Stratton, Sharon C. Porciatti, Vittorio Becker-André, Michael |
| description | The orphan nuclear receptor RORβ is expressed in areas of the central nervous system which are involved in the processing of sensory information, including spinal cord, thalamus and sensory cerebellar cortices. Additionally, RORβ localizes to the three principal anatomical components of the mammalian timing system, the suprachiasmatic nuclei, the retina and the pineal gland. RORβ mRNA levels oscillate in retina and pineal gland with a circadian rhythm that persists in constant darkness. RORβ
−/−
mice display a duck‐like gait, transient male incapability to sexually reproduce, and a severely disorganized retina that suffers from postnatal degeneration. Consequently, adult RORβ
−/−
mice are blind, yet their circadian activity rhythm is still entrained by light–dark cycles. Interestingly, under conditions of constant darkness, RORβ
−/−
mice display an extended period of free‐running rhythmicity. The overall behavioral phenotype of RORβ
−/−
mice, together with the chromosomal localization of the RORβ gene, suggests a close relationship to the spontaneous mouse mutation
vacillans
described >40 years ago. |
| doi_str_mv | 10.1093/emboj/17.14.3867 |
| format | Article |
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−/−
mice display a duck‐like gait, transient male incapability to sexually reproduce, and a severely disorganized retina that suffers from postnatal degeneration. Consequently, adult RORβ
−/−
mice are blind, yet their circadian activity rhythm is still entrained by light–dark cycles. Interestingly, under conditions of constant darkness, RORβ
−/−
mice display an extended period of free‐running rhythmicity. The overall behavioral phenotype of RORβ
−/−
mice, together with the chromosomal localization of the RORβ gene, suggests a close relationship to the spontaneous mouse mutation
vacillans
described >40 years ago.</description><identifier>ISSN: 0261-4189</identifier><identifier>EISSN: 1460-2075</identifier><identifier>DOI: 10.1093/emboj/17.14.3867</identifier><identifier>PMID: 9670004</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Ataxia - genetics ; Behavior, Animal ; Central Nervous System - chemistry ; Chromosome Mapping ; Chromosomes, Human, Pair 9 - genetics ; circadian ; Circadian Rhythm - genetics ; Evoked Potentials, Visual ; fertility ; Humans ; Infertility, Male - genetics ; Male ; Mice ; Mice, Transgenic ; nuclear receptor ; Phenotype ; Pineal Gland - chemistry ; Rats ; Rats, Sprague-Dawley ; Receptors, Retinoic Acid - analysis ; Receptors, Retinoic Acid - genetics ; Receptors, Retinoic Acid - physiology ; retina ; Retina - chemistry ; Retinal Degeneration - genetics ; RNA, Messenger - analysis ; spinal cord ; Suprachiasmatic Nucleus - chemistry</subject><ispartof>The EMBO journal, 1998-07, Vol.17 (14), p.3867-3877</ispartof><rights>European Molecular Biology Organization 1998</rights><rights>Copyright © 1998 European Molecular Biology Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5529-623fb50f4a81d5ff95f4a2f86c3186f1d1473496b4c65ce9ee08f930999bee673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170722/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170722/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9670004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>André, Elisabeth</creatorcontrib><creatorcontrib>Conquet, François</creatorcontrib><creatorcontrib>Steinmayr, Markus</creatorcontrib><creatorcontrib>Stratton, Sharon C.</creatorcontrib><creatorcontrib>Porciatti, Vittorio</creatorcontrib><creatorcontrib>Becker-André, Michael</creatorcontrib><title>Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice</title><title>The EMBO journal</title><addtitle>EMBO J</addtitle><addtitle>EMBO J</addtitle><description>The orphan nuclear receptor RORβ is expressed in areas of the central nervous system which are involved in the processing of sensory information, including spinal cord, thalamus and sensory cerebellar cortices. Additionally, RORβ localizes to the three principal anatomical components of the mammalian timing system, the suprachiasmatic nuclei, the retina and the pineal gland. RORβ mRNA levels oscillate in retina and pineal gland with a circadian rhythm that persists in constant darkness. RORβ
−/−
mice display a duck‐like gait, transient male incapability to sexually reproduce, and a severely disorganized retina that suffers from postnatal degeneration. Consequently, adult RORβ
−/−
mice are blind, yet their circadian activity rhythm is still entrained by light–dark cycles. Interestingly, under conditions of constant darkness, RORβ
−/−
mice display an extended period of free‐running rhythmicity. The overall behavioral phenotype of RORβ
−/−
mice, together with the chromosomal localization of the RORβ gene, suggests a close relationship to the spontaneous mouse mutation
vacillans
described >40 years ago.</description><subject>Animals</subject><subject>Ataxia - genetics</subject><subject>Behavior, Animal</subject><subject>Central Nervous System - chemistry</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>circadian</subject><subject>Circadian Rhythm - genetics</subject><subject>Evoked Potentials, Visual</subject><subject>fertility</subject><subject>Humans</subject><subject>Infertility, Male - genetics</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>nuclear receptor</subject><subject>Phenotype</subject><subject>Pineal Gland - chemistry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Retinoic Acid - analysis</subject><subject>Receptors, Retinoic Acid - genetics</subject><subject>Receptors, Retinoic Acid - physiology</subject><subject>retina</subject><subject>Retina - chemistry</subject><subject>Retinal Degeneration - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>spinal cord</subject><subject>Suprachiasmatic Nucleus - chemistry</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O0zAUhSMEGsrAng2SV6xIx078E2-QmGEYqIZBSKCR2FiOc9O6JHGwk0Jfg0fhQXgm3KaqYMOsbN9zz_G9-pLkKcFzgmV-Bm3p1mdEzAmd5wUX95IZoRynGRbsfjLDGScpJYV8mDwKYY0xZoUgJ8mJ5CI-6Cz5-doGP_aDdR1yNfIw2M7ZKvXQ6AEq5Hy_0l2sG-gH59HvX8jEwhICMtYbXdmolrDSG-v8C2T0GKK0j9ENqmAJHXi9j9ddhRrQVUCDQxttbNPoLqB-BZ0btj0g26HWGnicPKh1E-DJ4TxNPr-5_HTxNr3-cPXu4tV1ahjLZMqzvC4ZrqkuSMXqWrJ4zeqCm5wUvCYVoSKnkpfUcGZAAuCiljmWUpYAXOSnycsptx_LFioD3eB1o3pvW-23ymmr_lU6u1JLt1GECCyyLAY8PwR4922EMKjWBgO7tcCNQRUYZ5RSfGcj4SzLIprYiKdG410IHurjNASrHXC1B66IUISqHfBoefb3FkfDgXDU5aR_tw1s78xTl-_PF4JJggsZvWTyhmiLzL1au9FHsOF_86STx4YBfhz_0_6riqpg6vbmSt0uFjcfJfmiFvkfqb7eEQ</recordid><startdate>19980715</startdate><enddate>19980715</enddate><creator>André, Elisabeth</creator><creator>Conquet, François</creator><creator>Steinmayr, Markus</creator><creator>Stratton, Sharon C.</creator><creator>Porciatti, Vittorio</creator><creator>Becker-André, Michael</creator><general>John Wiley & Sons, Ltd</general><general>Nature Publishing Group UK</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19980715</creationdate><title>Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice</title><author>André, Elisabeth ; Conquet, François ; Steinmayr, Markus ; Stratton, Sharon C. ; Porciatti, Vittorio ; Becker-André, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5529-623fb50f4a81d5ff95f4a2f86c3186f1d1473496b4c65ce9ee08f930999bee673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Ataxia - genetics</topic><topic>Behavior, Animal</topic><topic>Central Nervous System - chemistry</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 9 - genetics</topic><topic>circadian</topic><topic>Circadian Rhythm - genetics</topic><topic>Evoked Potentials, Visual</topic><topic>fertility</topic><topic>Humans</topic><topic>Infertility, Male - genetics</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>nuclear receptor</topic><topic>Phenotype</topic><topic>Pineal Gland - chemistry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Retinoic Acid - analysis</topic><topic>Receptors, Retinoic Acid - genetics</topic><topic>Receptors, Retinoic Acid - physiology</topic><topic>retina</topic><topic>Retina - chemistry</topic><topic>Retinal Degeneration - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>spinal cord</topic><topic>Suprachiasmatic Nucleus - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>André, Elisabeth</creatorcontrib><creatorcontrib>Conquet, François</creatorcontrib><creatorcontrib>Steinmayr, Markus</creatorcontrib><creatorcontrib>Stratton, Sharon C.</creatorcontrib><creatorcontrib>Porciatti, Vittorio</creatorcontrib><creatorcontrib>Becker-André, Michael</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>André, Elisabeth</au><au>Conquet, François</au><au>Steinmayr, Markus</au><au>Stratton, Sharon C.</au><au>Porciatti, Vittorio</au><au>Becker-André, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice</atitle><jtitle>The EMBO journal</jtitle><stitle>EMBO J</stitle><addtitle>EMBO J</addtitle><date>1998-07-15</date><risdate>1998</risdate><volume>17</volume><issue>14</issue><spage>3867</spage><epage>3877</epage><pages>3867-3877</pages><issn>0261-4189</issn><eissn>1460-2075</eissn><abstract>The orphan nuclear receptor RORβ is expressed in areas of the central nervous system which are involved in the processing of sensory information, including spinal cord, thalamus and sensory cerebellar cortices. Additionally, RORβ localizes to the three principal anatomical components of the mammalian timing system, the suprachiasmatic nuclei, the retina and the pineal gland. RORβ mRNA levels oscillate in retina and pineal gland with a circadian rhythm that persists in constant darkness. RORβ
−/−
mice display a duck‐like gait, transient male incapability to sexually reproduce, and a severely disorganized retina that suffers from postnatal degeneration. Consequently, adult RORβ
−/−
mice are blind, yet their circadian activity rhythm is still entrained by light–dark cycles. Interestingly, under conditions of constant darkness, RORβ
−/−
mice display an extended period of free‐running rhythmicity. The overall behavioral phenotype of RORβ
−/−
mice, together with the chromosomal localization of the RORβ gene, suggests a close relationship to the spontaneous mouse mutation
vacillans
described >40 years ago.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>9670004</pmid><doi>10.1093/emboj/17.14.3867</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The EMBO journal, 1998-07, Vol.17 (14), p.3867-3877 |
| issn | 0261-4189 1460-2075 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1170722 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Ataxia - genetics Behavior, Animal Central Nervous System - chemistry Chromosome Mapping Chromosomes, Human, Pair 9 - genetics circadian Circadian Rhythm - genetics Evoked Potentials, Visual fertility Humans Infertility, Male - genetics Male Mice Mice, Transgenic nuclear receptor Phenotype Pineal Gland - chemistry Rats Rats, Sprague-Dawley Receptors, Retinoic Acid - analysis Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - physiology retina Retina - chemistry Retinal Degeneration - genetics RNA, Messenger - analysis spinal cord Suprachiasmatic Nucleus - chemistry |
| title | Disruption of retinoid-related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice |
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