Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

The Pax‐5 gene codes for the transcription factor BSAP which is essential for the progression of adult B lymphopoiesis beyond an early progenitor (pre‐BI) cell stage. Although several genes have been proposed to be regulated by BSAP, CD19 is to date the only target gene which has been genetically co...

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Veröffentlicht in:	The EMBO journal 1998-04, Vol.17 (8), p.2319-2333
Hauptverfasser:	Nutt, Stephen L., Morrison, Aline M., Dörfler, Petra, Rolink, Antonius, Busslinger, Meinrad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD19 - genetics Antigens, Surface - genetics Apoptosis Regulatory Proteins B lymphopoiesis B-Lymphocytes - chemistry B-Lymphocytes - metabolism CD79 Antigens Cell Membrane - metabolism DNA-Binding Proteins - genetics Gene Expression Regulation Genes, myc Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Humans Interleukin-7 - pharmacology LEF-1 Lymphoid Enhancer-Binding Factor 1 m6-1 Mice Mutagenesis N-myc Nuclear Proteins - genetics Pax-5 target genes PAX5 Transcription Factor Programmed Cell Death 1 Receptor Receptors, Antigen, B-Cell - genetics Transcription Factors - genetics
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