Downregulated CCND3 Is a Key Event Driving Lung Adenocarcinoma Metastasis during Acquired Cisplatin Resistance

Cyclin D3 (CCND3), a member of the cyclin D family, is known to promote cell cycle transition. In this study, we found that CCND3 was downregulated in cisplatin-resistant ( -diamminedichloroplatinum, DDP) lung adenocarcinoma (LUAD) cells. The loss of CCND3 indeed impeded cell cycle transition. Unexp...

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Veröffentlicht in:	International journal of biological sciences 2025, Vol.21 (2), p.708-724
Hauptverfasser:	Su, Yun, Ma, Yuting, Wang, Yubing, Xu, Ping, Guo, Miaoling, Cao, Haolin, Xin, Jianyang, Wu, Xi, Liu, Xiaoyan, Chen, Shan, Tao, Xingyu, Yang, Huiling, Cheng, Chao, Huang, Rongquan, Pan, Rongshuai, Pan, Yuexin, Zhou, Beixian, Fang, Weiyi, Liu, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung - drug therapy Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - metabolism Adenocarcinoma of Lung - pathology Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cell Line, Tumor Cisplatin - pharmacology Cisplatin - therapeutic use Cyclin D3 - genetics Cyclin D3 - metabolism Down-Regulation Drug Resistance, Neoplasm - genetics Epithelial-Mesenchymal Transition Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Nude Research Paper
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