Transformation abrogates an early G1-phase arrest point required for specification of the Chinese hamster DHFR replication origin

The origin decision point (ODP) was originally identified as a distinct point during G 1 ‐phase when Chinese hamster ovary (CHO) cell nuclei experience a transition that is required for specific recognition of the dihydrofolate reductase (DHFR) origin locus by Xenopus egg extracts. Passage of cells...

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Veröffentlicht in:	The EMBO journal 1998-03, Vol.17 (6), p.1810-1818
Hauptverfasser:	Wu, Jia-Rui, Keezer, Susan M., Gilbert, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - pharmacology Animals Antimetabolites - pharmacology Aphidicolin - pharmacology cell cycle Cell Transformation, Viral - physiology CHO Cells Cricetinae DNA replication DNA Replication - genetics Enzyme Inhibitors - pharmacology G1 Phase - drug effects G1 Phase - genetics origin decision point protein kinase Replication Origin - physiology S Phase - genetics Simian virus 40 - physiology Tetrahydrofolate Dehydrogenase - genetics transformation
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