Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome

Peptidyl‐tRNA dissociation from ribosomes is an energetically costly but apparently inevitable process that accompanies normal protein synthesis. The drop‐off products of these events are hydrolysed by peptidyl‐tRNA hydrolase. Mutant selections have been made to identify genes involved in the drop‐o...

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Veröffentlicht in:	The EMBO journal 1998-02, Vol.17 (3), p.808-816
Hauptverfasser:	Heurgué-Hamard, Valérie, Karimi, Reza, Mora, Liliana, MacDougall, Jane, Leboeuf, Céline, Grentzmann, Guido, Ehrenberg, Måns, Buckingham, Richard H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Carboxylic Ester Hydrolases - genetics Culture Media DNA Transposable Elements - genetics Escherichia coli - genetics Escherichia coli - growth & development Gene Expression Regulation, Bacterial Genes, Bacterial - genetics Guanosine Triphosphate - physiology Mutation - genetics Mutation - physiology Peptide Chain Termination, Translational - physiology Peptide Elongation Factor 2 Peptide Elongation Factors - metabolism Peptide Termination Factors - genetics Peptide Termination Factors - metabolism protein synthesis Proteins release factors RF3 RF4 Ribosomal Proteins ribosome Ribosomes - metabolism RNA, Transfer, Amino Acyl - metabolism Suppression, Genetic Temperature
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