Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

Raf‐1 kinase is a central regulator of mitogenic signal pathways, whereas its general role in signal transduction of tumour necrosis factor (TNF) is less well defined. We have investigated mechanisms of Raf‐1 regulation by TNF and its messenger ceramide in cell‐free assays, insect and mammalian cell...

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Veröffentlicht in:	The EMBO journal 1998-02, Vol.17 (3), p.732-742
Hauptverfasser:	Müller, Gertraud, Storz, Peter, Bourteele, Soizic, Döppler, Heike, Pfizenmaier, Klaus, Mischak, Harald, Philipp, Alex, Kaiser, Christian, Kolch, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Binding Sites - drug effects Carbon Radioisotopes Cells, Cultured ceramide Ceramides - pharmacology Ceramides - physiology COS Cells Enzyme Activation - drug effects epidermal growth factor Epidermal Growth Factor - pharmacology Guanosine Triphosphate - metabolism HeLa Cells Humans MAP Kinase Kinase 1 Mice Mitogen-Activated Protein Kinase Kinases Mitogens - pharmacology Mitogens - physiology Phosphorylation - drug effects Protein Binding - drug effects Protein-Serine-Threonine Kinases - drug effects Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - drug effects Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-raf - drug effects Proto-Oncogene Proteins c-raf - metabolism Raf-1 kinase Ras ras Proteins - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology tumour necrosis factor
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