Termination of cytosolic Ca2+ signals: Ca2+ reuptake into intracellular stores is regulated by the free Ca2+ concentration in the store lumen

The mechanism by which agonist‐evoked cytosolic Ca 2+ signals are terminated has been investigated. We measured the Ca 2+ concentration inside the endoplasmic reticulum store of pancreatic acinar cells and monitored the cytoplasmic Ca 2+ concentration by whole‐cell patch‐clamp recording of the Ca 2+...

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Veröffentlicht in:	The EMBO journal 1998-01, Vol.17 (2), p.435-442
Hauptverfasser:	Mogami, Hideo, Tepikin, Alexei V., Petersen, Ole H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Calcium - metabolism Calcium - physiology calcium pump Calcium-Transporting ATPases - drug effects Calcium-Transporting ATPases - metabolism Cell Separation cytoplasm Cytosol - drug effects Cytosol - enzymology Cytosol - metabolism endoplasmic reticulum Intracellular Fluid - drug effects Intracellular Fluid - enzymology Intracellular Fluid - metabolism Mice Pancreas - cytology Pancreas - enzymology Pancreas - metabolism Patch-Clamp Techniques signal termination Signal Transduction - drug effects Thapsigargin - pharmacology
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