Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for Ras in regulating the expression of muscarinic receptors and G proteins

We propose a novel mechanism for the regulation of the processing of Ras and demonstrate a new function for Ras in regulating the expression of cardiac autonomic receptors and their associated G proteins. We have demonstrated previously that induction of endogenous cholesterol synthesis in cultured...

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Veröffentlicht in:	The EMBO journal 1997-12, Vol.16 (24), p.7250-7260
Hauptverfasser:	Gadbut, A.P, Wu, L.Y, Tang, D.J, Papageorge, A, Watson, J.A, Galper, J.B
Format:	Artikel
Sprache:	eng
Schlagworte:	alkyl (aryl) transferases Animals atrium binding proteins blood serum bza-5b cells Cells, Cultured chemical reactions Chick Embryo chicks cholesterol Cholesterol - metabolism culture media cytochemistry cytoplasm embryo (animal) enzyme inhibitors farnesylation farnesyltransferase G protein G Protein-Coupled Inwardly-Rectifying Potassium Channels gene expression Gene Expression Regulation GTP-Binding Proteins - biosynthesis guanosine triphosphate heart Heart Atria heart cells lipoprotein depleted serum messenger RNA Mevalonic Acid - metabolism Models, Biological Myocardium - metabolism myocytes Potassium Channels - biosynthesis Potassium Channels, Inwardly Rectifying promoter regions Protein Prenylation Ras ras protein ras Proteins - metabolism receptors Receptors, Muscarinic - biosynthesis Recombinant Proteins - biosynthesis RNA, Messenger - biosynthesis Transcription, Genetic Transfection
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