Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

The budding yeast Cdc6 protein (Cdc6p) is essential for formation of pre‐replicative complexes (pre‐RCs) at origins of DNA replication. Regulation of pre‐RC assembly plays a key role in making initiation of DNA synthesis dependent upon passage through mitosis and in limiting DNA replication to once...

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Veröffentlicht in:	The EMBO journal 1997-10, Vol.16 (19), p.5966-5976
Hauptverfasser:	Drury, L.S, Perkins, G, Diffley, J.F.X
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid sequences Anaphase-Promoting Complex-Cyclosome binding proteins Binding Sites Cell Cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cullin Proteins DNA replication DNA-binding proteins F-Box Proteins Fungal Proteins - genetics Fungal Proteins - metabolism interactions Ligases - genetics Ligases - metabolism Mutagenesis, Site-Directed mutants mutation pre-replicative complex Protein Processing, Post-Translational proteolysis Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Suppression, Genetic Ubiquitin-Protein Ligase Complexes Ubiquitin-Protein Ligases
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