Sci-ModoM: a quantitative database of transcriptome-wide high-throughput RNA modification sites
We present Sci-ModoM, the first next-generation RNome database offering a holistic view of the epitranscriptomic landscape. Sci-ModoM has a simple yet powerful interface, underpinned by FAIR data principles, a standardized nomenclature, and interoperable formats, fostering the use of common standard...
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| Veröffentlicht in: | Nucleic acids research 2025-01, Vol.53 (D1), p.D310-D317 |
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| container_title | Nucleic acids research |
| container_volume | 53 |
| creator | Boileau, Etienne Wilhelmi, Harald Busch, Anne Cappannini, Andrea Hildebrand, Andreas Bujnicki, Janusz M Dieterich, Christoph |
| description | We present Sci-ModoM, the first next-generation RNome database offering a holistic view of the epitranscriptomic landscape. Sci-ModoM has a simple yet powerful interface, underpinned by FAIR data principles, a standardized nomenclature, and interoperable formats, fostering the use of common standards within the epitranscriptomics community. Sci-ModoM provides quantitative measurements per site and dataset, enabling users to assess confidence levels based on score, coverage, and stoichiometry. Data in Sci-ModoM is directly traceable to its sources. Users can Search and Compare over six million modifications across 156 datasets, Browse or download datasets, and retrieve metadata. A comparison tool offers a novel and unique opportunity to compare modifications site-wise across datasets, with the ability to securely upload and compare user data against latest published research. Sci-ModoM empowers researchers, including non-experts, to access a broad spectrum of recent quantitative RNA modification data, thereby enhancing the utility and impact of latest discoveries, and opening new avenues in biological and medical research. |
| doi_str_mv | 10.1093/nar/gkae972 |
| format | Article |
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| source | Oxford Journals Open Access Collection; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Database Issue Databases, Genetic Databases, Nucleic Acid High-Throughput Nucleotide Sequencing Humans RNA - chemistry RNA - genetics RNA Processing, Post-Transcriptional Software Transcriptome - genetics User-Computer Interface |
| title | Sci-ModoM: a quantitative database of transcriptome-wide high-throughput RNA modification sites |
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