Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways

The interferon‐inducible double‐stranded RNA protein kinase PKR controls protein synthesis through the phosphorylation of eukaryotic translation initiation factor (eIF)‐2. In addition to its demonstrated role in translational control, several reports have suggested a transcriptional role for PKR. He...

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Veröffentlicht in:	The EMBO journal 1997-03, Vol.16 (6), p.1291-1304
Hauptverfasser:	Wong, Andrew Hoi-Tao, Tam, Nancy Wai Ning, Yang, Yi-Li, Cuddihy, Andrew R., Li, Suiyang, Kirchhoff, Sabine, Hauser, Hansjörg, Decker, Thomas, Koromilas, Antonis E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Base Sequence DNA - genetics DNA - metabolism DNA binding DNA-Binding Proteins - metabolism double-stranded RNA eIF-2 Kinase HeLa Cells Humans interferon Interferons - metabolism Mice Mutation Phosphorylation Protein Binding protein phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Double-Stranded - metabolism Signal Transduction STAT1 Transcription Factor Trans-Activators - metabolism Transcriptional Activation Transfection
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