Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes

Hepatocyte growth factor induces proliferation, motility and differentiation of epithelial cells through the tyrosine kinase receptor encoded by the MET proto‐oncogene. The cytoplasmic portion of Met (referred to as cyto‐Met) is activated but only weakly transforming. In order to determine the effec...

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Veröffentlicht in:	The EMBO journal 1997-02, Vol.16 (3), p.495-503
Hauptverfasser:	Amicone, Laura, Spagnoli, Francesca M., Späth, Gerald, Giordano, Silvia, Tommasini, Cristina, Bernardini, Silvia, De Luca, Veronica, Rocca, Carlo Della, Weiss, Mary C., Comoglio, Paolo M., Tripodi, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - genetics Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Apoptosis - genetics Apoptosis - physiology apoptosis protection Blotting, Northern Blotting, Southern Blotting, Western Cell Differentiation - genetics cell polarity Cells, Cultured Gene Expression Regulation, Developmental - genetics Hepatocyte Growth Factor - metabolism Histocytochemistry Humans immortalized hepatocytes Immunohistochemistry Liver - metabolism Met Mice Mice, Transgenic Microscopy, Electron Proto-Oncogenes - genetics Receptor Protein-Tyrosine Kinases - genetics Transgenes - genetics
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