Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas

Acceleration of lymphomagenesis in oncogene‐bearing transgenic mice by slow‐transforming retroviruses has proven a valuable tool in identifying cooperating oncogenes. We have modified this protocol to search for genes that can collaborate effectively with the transgene in later stages of tumor devel...

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Veröffentlicht in:	The EMBO journal 1997-02, Vol.16 (3), p.441-450
Hauptverfasser:	Jonkers, Jos, Korswagen, Hendrik C., Acton, Dennis, Breuer, Marco, Berns, Anton
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Southern Blotting, Western Cloning, Molecular DNA Probes - genetics Flow Cytometry Gene Expression Regulation, Neoplastic - genetics insertional mutagenesis Lymphoma, T-Cell - metabolism Mice Mice, Transgenic Molecular Sequence Data Moloney leukemia virus Moloney murine leukemia virus - metabolism Neoplasms, Experimental - metabolism Neoplasms, Experimental - virology oncogenes Proto-Oncogenes - genetics Restriction Mapping Sequence Alignment Sequence Analysis Staining and Labeling T-cell lymphoma Transduction, Genetic - genetics transgenic mice
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