The value of GLI1 and p16 immunohistochemistry in the premolecular screening for GLI1-altered mesenchymal neoplasms

Mesenchymal neoplasms with GLI1 alterations have recently been reported in several anatomic locations. Their morphology and immunohistochemistry (IHC) are nonspecific, making their recognition a true challenge. To assess the diagnostic value of GLI1 and p16 IHC for identifying GLI1 -altered neoplasm...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2024-05, Vol.484 (5), p.765-775
Hauptverfasser:	Machado, Isidro, Agaimy, Abbas, Giner, Francisco, Navarro, Samuel, Michal, Michael, Bridge, Julia, Claramunt, Reyes, López-Guerrero, José Antonio, Alcacer, Javier, Linos, Konstantinos, Llombart-Bosch, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cyclin-Dependent Kinase Inhibitor p16 - analysis Cyclin-Dependent Kinase Inhibitor p16 - metabolism Female Glomus Tumor - diagnosis Glomus Tumor - pathology Humans Immunohistochemistry Liposarcoma Male MDM2 protein Medicine Medicine & Public Health Morphology Neoplasms Neoplasms, Connective and Soft Tissue - diagnosis Neoplasms, Connective and Soft Tissue - pathology Original Article Pathology Sarcoma Sarcoma, Ewing - diagnosis Sarcoma, Ewing - pathology Sensitivity Tumors Zinc Finger Protein GLI1 - analysis Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism
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